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Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, C. M.; Louro, T.; Matafome, P.; Nunes, E.; Monteiro, P.; Seiça, R.Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-...
Sena, C. M.; Nunes, E.; Louro, T.; Proença, T.; Fernandes, R.; Boarder, M. R.; Seiça, R. M.Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA...
Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat
Sena, C. M.; Barosa, C.; Nunes, E.; Seiça, R.; Jones, J. G.Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had higher fasting plasma insulin (219 ± 50 versus 44 ± 14 pmol/l, P < 0.002) and glucose (9.2 ± 2.3 versus 5.5 ± 0.5 mmol/l, P < 0.025). GK rats showed impaired glucose tolerance (IPGTT 2 h p...
Soybean oil treatment impairs glucose-stimulated insulin secretion and changes ...
Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.; Santos, M.; Matafome, P.; Moreira, P.; Seiça, R.Abstract We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective islet insulin secretion when compared with untreated Wistar rats. The decrease in insul...
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