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Polycyclic Aromatic Hydrocarbons May Contibute for Prostate Cancer Progression
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana; Mota-Pinto, AnabelaProstate cancer is the most common form of cancer affecting men in the Western world. Risk factors include ageing, genetics, recurrent inflammation, lifestyle and diet intake, related to an increase of oxidative stress. Prostate cancer risk is also associated with exposure to carcinogen such as polycyclic aromatic hydrocarbons (PAHs), originated from the incomplete combustion of carbon-containing fuels like tob...
Human periprostatic adipose tissue promotes prostate cancer aggressiveness in v...
Ribeiro, Ricardo; Monteiro, Cátia; Cunha, Virgínia; Oliveira, Maria José; Freitas, Mariana; Fraga, Avelino; Príncipe, Paulo; Lobato, CarlosBackground - Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer. Methods - Supernatants of whole adipose tissue (explants) or ...
Oxidative stress adaptation in aggressive prostate cancer may be counteracted b...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate can...
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, AnabelaDocetaxel and sodium selenite are well known for their anticancer properties. While resistance to docetaxel remains an obstacle in prostate cancer chemotherapy, sodium selenite, has been exploited as a new therapeutic approach. Currently, development of therapies affecting a multitude of cell targets, have been proposed as a strategy to overcome drug resistance. This association may reduce systemic toxicity cou...
Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Pr...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Pascoal, Rui; Rabaça, Carlos; Valido, Frederico; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaCigarette smoke is an oxidant, creating free radicals that are involved in carcinogenesis namely in Prostate Cancer (PC). However, a correlation between cigarette smoking and PC progression remains unclear. This study was directed to evaluate the correlation between cigarette smoking, Oxidative Stress (OS) and PC development and progression. The Total Antioxidant Status (TAS), Glutathione (GSH) and Malondialdeh...
Simultaneous analysis of cytoskeletal patterns and chromosome positioning in hu...
Ramalho-Santos, João; Amaral, Alexandra; Brito, Raquel; Freitas, Mariana; Santos, Teresa AlmeidaTo sequentially and reliably apply both tubulin immunocytochemistry (ICC) and fluorescence in situ hybridization (FISH) to human fertilization failures, thus providing a tool for a multiple analysis of arrest.Design ; http://www.sciencedirect.com/science/article/B6T6K-4F015R3-Y/1/452eda15f64fea3f4d2197c60885d819
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