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Pullulan-based nanoparticles as carriers for transmucosal protein delivery
Dionísio, Marita; Cordeiro, Clara; Remuñán-López, Carmen; Seijo, Begoña; Costa, Ana M. Rosa da; Grenha, AnaPolymeric nanoparticles have revealed very effective in transmucosal delivery of proteins. Polysaccharides are among the most used materials for the production of these carriers, owing to their structural flexibility and propensity to evidence biocompatibility and biodegradability. In parallel, there is a preference for the use of mild methods for their production, in order to prevent protein degradation, ensur...
The potential of chitosan for pulmonary drug delivery
Grenha, Ana; Al-Qadi, Sonia; Seijo, Begoña; Remuñán-López, CarmenThe administration of drugs through the pulmonary route offers great advantages, but also requires overcoming many challenges. There is a need to develop appropriate carriers for each active molecule to be delivered to the desired site in the lung, either for a local or a systemic effect. The polysaccharide chitosan is a very promising material for this purpose, given its demonstrated properties of biodegradabi...
Mucosal delivery of liposome-chitosan nanoparticles complexes
Carvalho, Edison Samir Mascarelhas; Grenha, Ana; Remuñán-López, Carmen; Alonso, Maria José; Seijo, BegoñaDesigning adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been refer...
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