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Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, C. M.; Louro, T.; Matafome, P.; Nunes, E.; Monteiro, P.; Seiça, R.Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisóstomo, J.; Rodrigues, L.; Moedas, A. R.; Monteiro, P.; Cipriano, A.; Seiça, R.Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto–Kakizaki rats were ...
Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, CM; Louro, T; Matafome, P; Nunes, E; Monteiro, P; Seiça, RDiabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-...
Sena, C. M.; Nunes, E.; Louro, T.; Proença, T.; Fernandes, R.; Boarder, M. R.; Seiça, R. M.Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA...
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P; Nunes, E; Louro, T; Amaral, C; Crisóstomo, J; Rodrigues, L; Moedas, AR; Monteiro, P; Cipriano, MA; Seiça, RNon-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto-Kakizaki rats were ...
Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat
Sena, C. M.; Barosa, C.; Nunes, E.; Seiça, R.; Jones, J. G.Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had higher fasting plasma insulin (219 ± 50 versus 44 ± 14 pmol/l, P < 0.002) and glucose (9.2 ± 2.3 versus 5.5 ± 0.5 mmol/l, P < 0.025). GK rats showed impaired glucose tolerance (IPGTT 2 h p...
Soybean oil treatment impairs glucose-stimulated insulin secretion and changes ...
Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.; Santos, M.; Matafome, P.; Moreira, P.; Seiça, R.Abstract We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective islet insulin secretion when compared with untreated Wistar rats. The decrease in insul...
Histological changes and impairment of liver mitochondrial bioenergetics after ...
Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, RThis study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measur...
Decreased Susceptibility of Heart Mitochondria from Diabetic GK Rats to Mitocho...
Oliveira, Paulo; Rolo, Anabela; Seiça, R.; Palmeira, Carlos; Santos, M. S.; Moreno, AntónioType 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death...
Alterations of liver mitochondrial bioenergetics in diabetic Goto-Kakizaki rats
Ferreira, F. M. L.; Palmeira, C. M.; Seiça, R.; Santos, M. S.Respiratory indexes and the transmembrane electrical potential ([Delta][Psi]) were evaluated in mitochondrial preparations from 6-month-old Goto-Kakizaki (GK) and Wistar rats in the presence of glutamate + malate and succinate. We found that in diabetic GK mitochondria, flavin adenine dinucleotide (FAD)-linked respiratory indexes (respiratory control ratio [RCR] and adenosine diphosphate [ADP] to oxygen ratio [...
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