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Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M.; Carmo, NB.; Krumeich, S.; Fanget, I.; Raposo, G.; Savina, A.; Moita, CF.; Schauer, K.; Hume, AN.; Freitas, RP.; Goud, B.; Benaroch, P.

Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes could be involved in intercellular communication and in the pathogenesis of infectious and degenerative diseases. The molecular mechanisms of exosome biogenesis and secretion are, however, poorly understood. Using an RNA interference (RNAi) screen,...

Data: 2010 | Origem: ARCA - Access to Research and Communication Annals

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Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranyl...

Baron, RA.; Tavare, R.; Figueiredo, AC.; Blazewska, KM.; Kashemirov, BA.; McKenna, CE.; Ebetino, FH.; Taylor, A.; Rogers, MJ.; Coxon, FP.; Seabra, MC.

Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC). The phosphonocarboxylates used were 3-PEHPC, which was previously report...

Data: 2009 | Origem: ARCA - Access to Research and Communication Annals

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