Encontrados 4 documentos, a visualizar página 1 de 1
Long-term effects of tafamidis for the treatment of transthyretin familial amyl...
Coelho, T.; Maia, L.; Martins-Silva, A.; Cruz, M.; Planté-Bordeneuve, V.; Suhr, O.; Conceição, I.; Schmidt, H.; Trigo, P.; Kelly, J.; Labaudinière, R.Tafamidis, a transthyretin (TTR) kinetic stabilizer, delayed neuropathic progression in patients with Val30Met TTR familial amyloid polyneuropathy (TTR-FAP) in an 18-month randomized controlled trial (study Fx-005). This 12-month, open-label extension study evaluated the long-term safety, tolerability, and efficacy of tafamidis 20 mg once daily in 86 patients who earlier received blinded treatment with tafamidi...
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE coll...
Traylor, M.; Farrall, M.; Holliday, E.G.; Sudlow, C.; Hopewell, J.C.; Cheng, Y.C.; Fornage, M.; Ikram, M.A.; Malik, R.; Bevan, S.; Thorsteinsdottir, U.Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.
Hydrogels for nucleus replacement : facing a biomechanical challenge
Reitmaier, S.; Wolfram, U.; Ignatius, A.; Wilke, H. - J.; Gloria, A.; Martín-Martínez, José M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Hydrogelsareconsideredpromisingfordiscregenerationstrategies.However,itiscurrently unknownwhetherthedestructionofthenaturalinterfacebetweennucleusandsurrounding structurescausedbynucleotomyandaninadequateannulusclosurediminishesthemechan- ical competenceofthedisc.This in vitro studyaimedtoclarifythesemechanismsandto evaluatewhetherhydrogelsareabletorestorethebiomechanicalbehaviourofthedisc. Nucleuspressureinano...
Space charge and dipoles in polyvinylidenefluoride
Eisenmenger,W.; Schmidt,H.; Dehlen,B.The properties of space charge (homocharge) and dipoles (heterocharge) in various electrets have been in the focus of interest since the investigations of B. Gross on carnauba wax. In this article we present a review on the role and the interaction of charges and dipoles in the polymeric electret polyvinylidenefluoride (PVDF). It covers the importance of charge injection for the orientation of the dipoles at lo...
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