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A comparative analysis of scaffold material modifications for load-bearing appl...
Chim, H.; Hutmacher, D. W.; Chou, A.; Oliveira, A. L.; Reis, R. L.; Lim, T. C.; Schantz, J. T.To facilitate optimal application of appropriate scaffold architectures for clinical trials, there is a need to compare different scaffold modifications under similar experimental conditions. In this study was assessed the effectiveness of poly-e-caprolactone (PCL) scaffolds fabricated by fused deposition modelling (FDM), with varying material modifications, for the purposes of bone tissue engineering. The inco...
Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells ...
Endres, M.; Hutmacher, D. W.; Salgado, A. J.; Kaps, C.; Ringe, J.; Reis, R. L.; Sittinger, M.; Brandwood, A.; Schantz, J. T.The aim of this project was to investigate the in vitro osteogenic potential of human mesenchymal progenitor cells in novel matrix architectures built by means of a three-dimensional bioresorbable synthetic framework in combination with a hydrogel. Human mesenchymal progenitor cells (hMPCs) were isolated from a human bone marrow aspirate by gradient centrifugation. Before in vitro engineering of scaffold-hMPC c...
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