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Overexpression of delta-like 4 induces arterialization and attenuates
Trindade, A.; Kumar, S.R.; Scehnet, J.S.; Lopes-da-Costa, L.; Becker, J.D.The importance of Notch signaling pathway in the regulation of vascular development and angiogenesis is suggested by the expression of Notch receptors and ligands in vascular endothelial cells (ECs) and the observed vascular phenotypes in mutants of Notch receptors or ligands, especially Dll4. DLL4 is specifically expressed in arterial ECs during development, and haplo-insufficiency is embryonically lethal in m...
Data: 2008
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Origem: ARCA - Access to Research and Communication Annals
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