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Platelet iysate maintains chondrogenic potential and promotes cartilage regener...
Pereira, R. C.; Scaranari, M.; Strada, P.; Reis, R. L.; Cancedda, Ranieri; Gentili, Chiaracartilage. We report the biological effect of the platelet lysate (PL), a PRP derivative, on primary human articular chondrocytes (HAC) cultured under both physiological and inflammatory condition. Added to the culture medium, PL induced a strong mitogenic response in the chondrocytes. The in vitro expanded cell population maintained a chondrogenic re-‐differentiation potential as revealed by micromass culture...
Novel injectable gel (system) as a vehicle for human articular chondrocytes in ...
Pereira, Rui C.; Scaranari, M.; Castagnola, P.; Grandizio, M.; Azevedo, Helena S.; Reis, R. L.; Cancedda, Ranieri; Gentili, ChiaraWe developed a novel injectable carrageenan/fibrin/hyaluronic acid-based hydrogel with in situ gelling properties to be seeded with chondrogenic cells and used for cartilage tissue engineering applications. We first analysed the distribution within the hydrogel construct and the phenotype of human articular chondrocytes (HACs) cultured for 3 weeks in vitro. We observed a statistically significant increase in th...
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