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EGFR amplification and lack of activating mutations in metaplastic breast carci...
Reis Filho, Jorge S.; Pinheiro, Céline; Lambros, M. B. K.; Milanezi, Fernanda; Carvalho, Silvia; Savage, K.; Simpson, Pete T.; Jones, C.; Swift, S.Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the underlying genetic mechanism in around one-third of these. In this study, EGFR gene amplification as defined by chromogenic in situ hybridization and protein overexpression was examined in a cohort of 47 metaplastic breast carcinomas. Furtherm...
Metaplastic breast carcinomas are basal-like tumours
Reis Filho, Jorge S.; Milanezi, Fernanda; Steele, D.; Savage, K.; Simpson, Pete T.; Nesland, J. M.; Pereira, Emílio M.; Lakhani, Sunil R.Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (...
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