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Polycyclic Aromatic Hydrocarbons May Contibute for Prostate Cancer Progression
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana; Mota-Pinto, AnabelaProstate cancer is the most common form of cancer affecting men in the Western world. Risk factors include ageing, genetics, recurrent inflammation, lifestyle and diet intake, related to an increase of oxidative stress. Prostate cancer risk is also associated with exposure to carcinogen such as polycyclic aromatic hydrocarbons (PAHs), originated from the incomplete combustion of carbon-containing fuels like tob...
Oxidative stress adaptation in aggressive prostate cancer may be counteracted b...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate can...
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, AnabelaDocetaxel and sodium selenite are well known for their anticancer properties. While resistance to docetaxel remains an obstacle in prostate cancer chemotherapy, sodium selenite, has been exploited as a new therapeutic approach. Currently, development of therapies affecting a multitude of cell targets, have been proposed as a strategy to overcome drug resistance. This association may reduce systemic toxicity cou...
CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukae...
Dourado, Marília; Sarmento-Ribeiro, Ana Bela; Vale-Pereira, Sofia; Alves, Vera; Silva, Teresa; Mota-Pinto, Anabela; Santos-Rosa, ManuelDipeptidyl peptidase IV, a cell membrane surface protease also known as CD26 (CD26/DPPIV), is known to play multiple functions in human organism, where it is largely expressed, for instance, in the development of human cancer and metastasis as well as in chemotherapy response. The objective of this work was to study the CD26 membrane expression and DPPIV activity in T-acute leukaemia cell lines (CEM and MOLT3) ...
Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Pr...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Pascoal, Rui; Rabaça, Carlos; Valido, Frederico; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaCigarette smoke is an oxidant, creating free radicals that are involved in carcinogenesis namely in Prostate Cancer (PC). However, a correlation between cigarette smoking and PC progression remains unclear. This study was directed to evaluate the correlation between cigarette smoking, Oxidative Stress (OS) and PC development and progression. The Total Antioxidant Status (TAS), Glutathione (GSH) and Malondialdeh...
Transfection of oral cancer cells mediated by transferrin-associated lipoplexes...
Neves, Sílvia S.; Sarmento-Ribeiro, Ana B.; Simões, Sérgio P.; Pedroso de Lima, Maria C.The Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach has been used for the treatment of a variety of cancers. The purpose of the present study was to evaluate the cytotoxic effect of ganciclovir in oral squamous cancer cells, previously transfected with HSV-tk gene delivered by transferrin-associated complexes (Tf-lipoplexes), as well as to investigate the mechanisms involv...
Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)
Dourado, Marília; Bento, Joana; Mesquita, Luis; Marques, Alcide; Vale-Pereira, Sofia; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, AnabelaSarcoidosis is a systemic disease of unknown aetiology, morphologically characterized by well-formed epithelioid granulomas, which show little or no central necrosis. These may be present in any organ or tissue. The lung is the most frequently and prominently involved target. The granuloma is often very sharply demarcated from the adjacent tissue and is surrounded by a mantle of lymphocytes, which mediate lysis...
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