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Biguanides in the treatment of diabetes mellitus.
Saraiva, A MBiguanides are useful drugs in diabetes but their indications are very precise. The danger of lactic acidosis can be avoided with the use of metformin, the less toxic of biguanides, and strict respect for contraindications. All biguanides have a similar action, through different pharmacokinetics, and besides their hypoglycemic effect, have a favourable action on blood lipids, which increases their usefulness. H...
The endocrine pancreas.
Cortesão, L; Serviço de Endocrinologia Diabetes e Metabolismo, Hospital de Egas Moniz, Lisboa.; Saraiva, A M; Guerreiro, LThe islets of Langerhans provide energy storage and disposal, and protection from plasma glucose excursions, especially hypoglycemia. Insulin-dependent diabetes mellitus (IDDM) results from autoimmune beta-cell damage. Prevention of IDDM has already been achieved in animal investigation and some centers are now screening and treating individuals at high risk for developing IDDM. Immunosuppressive drugs can indu...
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