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Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...

Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...

The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced perme...

The combination of isotretinoin (13-cis-retinoic acid) with antiestrogens seems to be a promising strategy for cancer chemotherapy. The aim of the study was to evaluate the effects of isotretinoin alone or in combination with 4-hydroxytamoxifen (OHTAM) and with its prodrug tamoxifen (TAM), on the functions of rat liver mitochondria, i.e., mitochondrial permeability transition (MPT), bioenergetic functions and a...

Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome pa...

A significant different allelic distribution, in Gilbert patients and in controls, was found for two promoter polymorphisms. Among patients, 82.2% were homozygous and 17.8% heterozygous for the c.− 41_ − 40dupTA allele; in control group, 9.9% were homozygous and 43.5% heterozygous for this promoter variant, while 46.6% (n = 75) presented the [A(TA)6TAA]. For the T>G transition at c.− 3279 promoter region, in pa...

Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental ...

Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinog...

Variação Inter-Individual nos Níveis de Bilirrubina: O papel de Factores Genéti...

Variação Inter-Individual nos Níveis de Bilirrubina: O papel de Factores Genéti...

Prediction of deleterious nsSNPs in human UGT1A1 gene by web available algorith...

Variação inter-individual nos níveis de bilirrubina: o papel dos factores genét...

A bilirrubina é um pigmento biliar que deriva principalmente do catabolismo da hemoglobina. É um marcador bioquímico de doenças hepáticas e hematológicas e tem vindo a ser alvo de interesse devido à sua capacidade antioxidante. O objectivo deste trabalho foi avaliar a contribuição de vários factores para a variação da concentração da bilirrubina sérica na população portuguesa. Foi analisado o contributo dos pol...

Variação inter-individual nos níveis de bilirrubina: o papel dos factores genét...

A bilirrubina é um pigmento biliar que deriva principalmente do catabolismo da hemoglobina. É um marcador bioquímico de doenças hepáticas e hematológicas e tem vindo a ser alvo de interesse devido à sua capacidade antioxidante. O objectivo deste trabalho foi avaliar a contribuição de vários factores para a variação da concentração da bilirrubina sérica na população portuguesa. Foi analisado o contributo dos pol...

Prediction of deleterious nsSNPs in human UGT1A1 gene by web available algorith...

The uridine diphosphate glucuronosyltransferase (UGT1A1) belongs to the class of phase II enzymes involved in the metabolism and detoxification of numerous xenobiotic and endogenous compounds (e.g. bilirubin). Genotyping data lead to the discovery of over 100 single nucleotide polymorphisms (SNPs) within the UGT1A1 gene. Some of the non-synonymous (ns) SNPs (nsSNPs) of the human UGT1A1 gene variants have been a...