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Molecular aspects and comparative genomics of bacteriophage endolysins

Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with a widespread group of bacterial hosts. At the end of the infection cycle, progeny virions are confronted with a rigid cell wall that hinders their release into...

RecFinder – a new tool to find phage proteins responsible for host recognition

(Bacterio)phages are bacterial viruses that represent the most abundant and genetically diverse biological entities on the planet [1,2]. The largest virus group, the order Caudovirales (containing 96% of all known phages), has evolved recognition peptides for efficient virus-host interaction [3]. The peptides, usually located at the phage tail fiber, baseplate and other tail proteins mediate recognition and att...

Host-Endolysins interactions

37 Host-Endolysins interactions Franklin L. Nobrega, Silvio Santos, Eugénio C. Ferreira, Joana Azeredo, Leon D. Kluskens IBB – Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal Abstract (Bacterio)phages are viruses that specifically infect bacteria. They are tremendously diverse and the most abundant living entiti...

Molecular and functional aspects of bacteriophage endolysins

Serviço Público de Radiodifusão em Portugal: do controlo ideológico ao fim da r...

Tese de doutoramento em Letras, na área de Ciências da Comunicação, na especialidade de Media e Sociedade, apresentada à Faculdade de Letras da Universidade de Coimbra

Characterization of modular bacteriophage endolysins from Myoviridae phages OBP...

Peptidoglycan lytic enzymes (endolysins) induce bacterial host cell lysis in the late phase of the lytic bacteriophage replication cycle. Endolysins OBPgp279 (from Pseudomonas fluorescens phage OBP), PVP-SE1gp146 (Salmonella enterica serovar Enteritidis phage PVP-SE1) and 201φ2-1gp229 (Pseudomonas chlororaphis phage 201φ2-1) all possess a modular structure with an N-terminal cell wall binding domain and a C-ter...

Insights into phage endolysins

(Bacterio)phages are viruses that specifically infect bacteria, and thus are harmless to humans, animals, and plants. They are the most abundant microorganisms on the planet (estimated to be 1031 on Earth) in a ratio of 10 times more than bacteria (1). Consequently, even rare phage-induced events are frequent at the global level. Therefore, they have a staggering ecological impact on the bacterial population an...

The genome and proteome of a Campylobacter coli bacteriophage vB_CcoM-IBB_35 re...

Campylobacter is the leading cause of foodborne diseases worldwide. Bacteriophages (phages) are naturally occurring predators of bacteria, ubiquitous in the environment, with high host specificity and thus considered an appealing option to control bacterial pathogens. Nevertheless for an effective use of phages as antimicrobial agents, it is important to understand phage biology which renders crucial the analys...

Characterization of modular bacteriophage endolysins from giant phiKZ related m...

Peptidoglycan lytic enzymes (endolysins) of bacteriophages have a major role in bacterial lysis at the end of the phage replication cycle. These endolysins turned out to be potential antibacterial compounds to combat a broad range of Gram-positive pathogens, yet Gram-negative bacteria remain unharmed due to their impermeable outer membrane. With this background, we recently characterized three new endolysins fr...

Development of a predictive model for phage-bacteria interaction

The prevalence and impact of bacteriophages in the ecology of bacterial communities coupled with their ability to control pathogens turns essential to understand and predict the existing dynamics between phage and bacteria populations. The success of phage therapy is dependent on the knowledge of the phage replication kinetic properties in the presence of the host as well as on the prediction, controlling and o...