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Comparison of four verbal memory tests for the diagnosis and predictive value o...
Silva, Dina; Guerreiro, Manuela; Maroco, João; Santana, Isabel; Rodrigues, Ana; Marques, José Bravo; Mendonça, Alexandre deBackground: Mild cognitive impairment (MCI) is considered to be an early stage of a neurodegenerative disorder, particularly Alzheimer’s disease, and the clinical diagnosis requires the objective demonstration of cognitive deficits. The aim of the present study was to evaluate the predictive value of MCI for the conversion to dementia when using four different verbal memory tests (Logical Memory, LM; California...
Memory complaints associated with seeking clinical care
Pires, Carolina; Silva, Dina; Maroco, João; Ginó, Sandra; Mendes, Tiago; Schmand, Ben A.; Guerreiro, Manuela; Mendonça, Alexandre deDiagnosis of mild cognitive impairment relies on the presence of memory complaints. However, memory complaints are very frequent in healthy people. The objective of this study was to determine the severity and type of memory difficulties presented by elderly patients who seek for clinical help, as compared to the memory difficulties reported by subjects in the community. Assessment of subjective memory complain...
Data mining methods in the prediction of dementia: A real-data comparison of th...
Maroco, João; Silva, Dina; Rodrigues, Ana; Guerreiro, Manuela; Santana, Isabel; Mendonça, Alexandre deBackground: Dementia and cognitive impairment associated with aging are a major medical and social concern. Neuropsychological testing is a key element in the diagnostic procedures of Mild Cognitive Impairment (MCI), but has presently a limited value in the prediction of progression to dementia. We advance the hypothesis that newer statistical classification methods derived from data mining and machine learning...
Electrophysiological studies in healthy subjects involving caffeine
Carvalho, Mamede de; Marcelino, Erica; Mendonça, Alexandre deCopyright ©2012 IOS Press All rights reserved. ; We review the electrophysiological studies concerning the effects of caffeine on muscle, lower and upper motor neuron excitability and cognition. Several different methods have been used, such as electromyography, recruitment analysis, H-reflex, transcranial magnetic stimulation (TMS), electroencephalography and event-related potentials. The positive effect of c...
Caffeine, adenosine receptors, and synaptic plasticity
Costenla, Ana Rita; Cunha, Rodrigo A.; Mendonça, Alexandre deCopyright ©2012 IOS Press All rights reserved. ; Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordin...
Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerv...
Rodrigues, Ricardo; Almeida, Teresa; Mendonça, Alexandre de; Cunha, Rodrigohttp://dx.doi.org/10.1385/JMN:30:1:173
Mild cognitive impairment: Deficits in cognitive domains other than memory
Ribeiro, Filipa; Mendonça, Alexandre de; Guerreiro, ManuelaPatients with mild cognitive impairment (MCI) typically present with memory complaints, but may have mild deficits in other cognitive domains. We compared the neuropsychological profiles of a series of consecutive MCI patients (n = 116) with a control group of healthy elderly subjects (n = 63). The presence of a memory deficit on delayed recall was consistent in the MCI sample, as it was an inclusion criterion ...
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hi...
Rebola, Nelson; Sebastião, Ana M.; Mendonça, Alexandre de; Oliveira, Catarina R.; Ribeiro, J. A.; Cunha, Rodrigo A.Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors, respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) compared with young adult rats (2 mo), we tested if A2A receptor modulation of synaptic transmission was also increased in aged rats. The A2A receptor agonist, CGS21680 (10 nM), caused a larger facilitation of the field excitatory pos...
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