Encontrados 6 documentos, a visualizar página 1 de 1
High glucose induces caspase-independent cell death in retinal neural cells
Santiago, A. R.; Cristóvão, A. J.; Santos, P. F.; Carvalho, C. M.; Ambrósio, A. F.Diabetic retinopathy is a leading cause of blindness among adults in the western countries. It has been reported that neurodegeneration may occur in diabetic retinas, but the mechanisms underlying retinal cell death are poorly understood. We found that high glucose increased the number of cells with condensed nuclei and the number of TUNEL-positive cells, and caused an increase in the translocation of phosphati...
Changes in calcium dynamics following the reversal of the sodium-calcium exchan...
Araújo, I. M.; Carreira, B. P.; Pereira, T.; Santos, P. F.; Soulet, D.; Inácio, A.; Bahr, B. A.; Carvalho, A. P.; Carvalho, C. M.Proteolytic cleavage of the Na(+)/Ca(2+) exchanger (NCX) by calpains impairs calcium homeostasis, leading to a delayed calcium overload and excitotoxic cell death. However, it is not known whether reversal of the exchanger contributes to activate calpains and trigger neuronal death. We investigated the role of the reversal of the NCX in Ca(2+) dynamics, calpain activation and cell viability, in alpha-amino-3-hy...
Synthesis and spectroscopic characterisation of n-alkyl quaternary ammonium sal...
Pardal, Ana Cristina; Ramos, S.S.; Santos, P. F.; Reis, L. V.; Almeida, P.The synthesis and spectroscopic characterisation of some representative N-alkylsubstituted quaternary ammonium salts derived from benzothiazole, benzoxazole, benzoselenazole, indole and quinoline are described. These heterocyclic salts, bearing an activated methyl group in the 2-position in relation to the nitrogen atom and N-methyl, -pentyl, -hexyl and -decyl chains, are typical precursors of cyanine dyes.
Synthesis and spectroscopic characterisation of n-alkyl quaternary ammonium sal...
Pardal, Ana Cristina; Ramos, S.S.; Santos, P. F.; Reis, L. V.; Almeida, P.The synthesis and spectroscopic characterisation of some representative N-alkylsubstituted quaternary ammonium salts derived from benzothiazole, benzoxazole, benzoselenazole, indole and quinoline are described. These heterocyclic salts, bearing an activated methyl group in the 2-position in relation to the nitrogen atom and N-methyl, -pentyl, -hexyl and -decyl chains, are typical precursors of cyanine dyes.
Closed-form integration of singular terms for constant, linear and quadratic bo...
Tadeu, A. J. B.; Santos, P. F. A.; Kausel, E.Part I of these two related papers considered the analytical evaluation of singular integrals for anti-plane boundary elements, the results of which were then applied to the evaluation of scattering problems involving SH waves. This second part provides an extension of these results to the more complicated case of in-plane boundary elements, and presents their application to scattering problems involving SV-P w...
Closed-form integration of singular terms for constant, linear and quadratic bo...
Tadeu, A. J. B.; Santos, P. F. A.; Kausel, E.One of the most important aspects in the application of boundary element techniques to wave propagation problems is the accurate representation of the singular terms at the points of application of the virtual loads. It is current practice to carry out this task by means of numerical quadrature. This paper presents an analytical evaluation of the singular integrals for constant, linear and quadratic boundary el...
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