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A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
Vigant, Frederic; Lee, Jihye; Hollmann, Axel; Tanner, Lukas B.; Ataman, Zeynep Akyol; Yun, Tatyana; Shui, Guanghou; Aguilar, Hector C.; Zhang, Dong© 2013 Vigant et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 mM), and was...
Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-memb...
Hollmann, Axel; Matos, Pedro M.; Augusto, Marcelo T.; Castanho, Miguel A. R. B.; Santos, Nuno C.© 2013 Hollmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; Recently, the covalent binding of a cholesterol moiety to a classical HIV-1 fusion inhibitor peptide, C34, was shown to potentiate its antiviral activit...
Intracellular nucleic acid delivery by the supercharged dengue virus capsid pro...
Freire, João Miguel; Veiga, Ana Salomé; Conceição, Thaís M.; Kowalczyk, Wioleta; Mohana-Borges, Ronaldo; Andreu, David; Santos, Nuno C.© 2013 Freire et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian ce...
Translocating the blood-brain barrier using electrostatics
Ribeiro, Marta M. B.; Domingues, Marco M.; Freire, João M.; Santos, Nuno C.; Castanho, Miguel A. R. B.Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. ; Mammalian cell membranes regulate homeostas...
Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium...
Carvalho, Filomena A.; Carneiro, Fabiana A.; Martins, Ivo C.; Assunção-Miranda, Iranaia; Faustino, André F.; Pereira, Renata M.; Bozza, Patricia T.Copyright © 2012, American Society for Microbiology. All Rights Reserved. ; Dengue virus (DENV) affects millions of people, causing more than 20,000 deaths annually. No effective treatment for the disease caused by DENV infection is currently available, partially due to the lack of knowledge on the basic aspects of the viral life cycle, including the molecular basis of the interaction between viral components ...
Differential mesenteric fat deposition in bovines fed on silage or concentrate ...
Martins, Ana Paula; Lopes, Paula A.; Costa, Ana Sofia H.; Martins, Susana V.; Santos, Nuno C.; Prates, José A. M.; Moura, Teresa F.; Soveral, GraçaIn the meat industry, the manipulation of fat deposition in cattle is of pivotal importance to improve production efficiency, carcass composition and ultimately meat quality. There is an increasing interest in the identification of key factors and molecular mechanisms responsible for the development of specific fat depots. This study aimed at elucidating the influence of breed and diet on adipose tissue membran...
Nanomedicina – Ciência, Tecnologia e Educação
Santos, Nuno C.© Conselho Nacional de Ética para as Ciências da Vida
Using zeta-potential measurements to quantify peptide partition to lipid membranes
Freire, João M.; Domingues, Marco M.; Matos, Joana; Melo, Manuel N.; Veiga, Ana Salomé; Santos, Nuno C.; Castanho, Miguel A. R. B.© The Author(s) 2011. This article is published with open access at Springerlink.com. ; Open Access: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. ; Many cellular phenomena occur on the biomembranes. There are plenty...
Variations on fibrinogen-erythrocyte interactions during cell aging
Carvalho, Filomena A.; Oliveira, Sofia de; Freitas, Teresa; Gonçalves, Sónia; Santos, Nuno C.© 2011 Carvalho et al ; Erythrocyte hyperaggregation, a cardiovascular risk factor, is considered to be caused by an increase in plasma adhesion proteins, particularly fibrinogen. We have recently reported a specific binding between fibrinogen and an erythrocyte integrin receptor with a β3 or β3-like subunit. In this study we evaluate the influence of erythrocyte aging on the fibrinogen binding. By atomic forc...
Conjugated linoleic acid reduces permeability and fluidity of adipose plasma me...
Martins, Ana Paula; Lopes, Paula A.; Martins, Susana V.; Madeira, Ana; Santos, Nuno C.; Prates, José A. M.; Moura, Teresa F.; Soveral, GraçaNOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A defini...
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