Encontrados 14 documentos, a visualizar página 1 de 2
Clinical, physical and lifestyle variables and relationship with cognition and ...
Santos, Nadine Correia; Costa, Patr??cio Soares; Cunha, Pedro Miguel Guimar??es Marques da; Nunes, Carlos Portugal; Amorim, Liliana; Cotter, JorgeIt is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dimensions (memory and general executive function). Herein, the present study aimed to characteriz...
Telephone-based screening tools for mild cognitive impairment and dementia in a...
Castanho, Teresa C.; Amorim, Liliana; Zihl, Joseph; Palha, Joana Almeida; Sousa, Nuno; Santos, Nadine CorreiaThe decline of cognitive function in old age is a great challenge for modern society. The simultaneous increase in dementia and other neurodegenerative diseases justifies a growing need for accurate and valid cognitive assessment instruments. Although in-person testing is considered the most effective and preferred administration mode of assessment, it can pose not only a research difficulty in reaching large a...
Risk and clinical-outcome indicators of delirium in an emergency department int...
Mariz, José; Santos, Nadine Correia; Afonso, Hugo; Rodrigues, Pedro L.; Faria, António; Sousa, Nuno; Teixeira, JorgeWe are thankful to the staff at the EDIMCU of Hospital de Braga. ; Background Identification of delirium in emergency departments (ED) is often underestimated; within EDs, studies on delirium assessment and relation with patient outcome in Intermediate Care Units (IMCU) appear missing in European hospital settings. Here we aimed to determine delirium prevalence in an EDIMCU (Hospital de Braga, Braga, Portugal)...
Stress impact on resting state brain networks
Soares, José Miguel; Sampaio, Adriana; Ferreira, Luís Miguel; Santos, Nadine Correia; Marques, Fernanda; Palha, Joana Almeida; Cerqueira, JoãoResting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...
The use of Bayesian latent class cluster models to classify patterns of cogniti...
Costa, Patrício Soares; Santos, Nadine Correia; Cunha, Pedro; Palha, Joana Almeida; Sousa, NunoThe main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing. Principal component analysis (PCA) was used to detect main cognitive dimensions (based on the neurocognitive test variables) and Bayesian latent class analysis (LCA) models (without constraints) were used to explore patterns of cognitive performance among co...
The use of multiple correspondence analysis to explore associations between cat...
Costa, Patrício Soares; Santos, Nadine Correia; Cunha, Pedro; Cotter, Jorge; Sousa, NunoIn press ; Population studies are often characterized by a plethora of data that includes quantitative to qualitative variables. The main focus of this study was to illustrate the applicability of multiple correspondence analysis (MCA) in detecting and representing underlying structures in large datasets used to investigate cognitive ageing. Principal component analysis (PCA) was used to obtain main cognitive ...
Plasticity of resting state brain networks in recovery from stress
Marques, Fernanda; Palha, Joana Almeida; Cerqueira, Jo??o; Soares, Jos?? Miguel; Sousa, Nuno; Santos, Nadine Correia; Marques, Paulo C??sar Gon??alvesChronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodeling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs), but nothing is known about the plasticity of ...
Revisiting thyroid hormones in schizophrenia
Santos, Nadine Correia; Costa, Patrício Soares; Ruano, Dina; Macedo, António; Soares, Maria João; Valente, José; Pereira, Ana TelmaThyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosign...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevan...
Palha, Joana Almeida; Santos, Nadine Correia; Marques, Fernanda Cristina Gomes de Sousa; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, NunoSchizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that ...
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