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Design of nano- and microfiber combined scaffolds by electrospinning of collage...
Tuzlakoglu, K.; Santos, Marina I.; Neves, N. M.; Reis, R. L.Mimicking the structural organization and biologic function of natural extracellular matrix has been one of the main goals of tissue engineering. Nevertheless, the majority of scaffolding materials for bone regeneration highlights biochemical functionality in detriment of mechanical properties. In this work we present a rather innovative construct that combines in the same structure electrospun type I collagen ...
Vascularization in bone tissue engineering : physiology, current strategies, ma...
Santos, Marina I.; Reis, R. L.The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the estab...
Cellular aproaches and tailor-made 3D starch-based scaffolds for improved vascu...
Santos, Marina I.Tese de doutoramento em Engenharia Biológica ; The establishment of a vascular supply in bone grafts is presently identified as the main pitfall in bone tissue engineering and the major hurdle for the clinical application of the engineered constructs. Granted the importance of intraosseous vasculature in bone physiological processes, the existence of a microcirculation is not only essential to assure cell surv...
Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprol...
Santos, Marina I.; Unger, Ronald E.; Sousa, R. A.; Reis, R. L.; Kirkpatrick, C. JamesThe reconstruction of bone defects based on cell-seeded constructs requires a functional microvasculature that meets the metabolic demands of the engineered tissue. Therefore, strategies that augment neovascularization need to be identified. We propose an in vitro strategy consisting of the simultaneous culture of osteoblasts and endothelial cells on a starch-based scaffold for the formation of pre-vascular str...
Endothelial cell colonization and angiogenic potential of combined nano- and mi...
Santos, Marina I.; Tuzlakoglu, K.; Fuchs, Sabine; Gomes, Manuela E.; Peters, K.; Piskin, Erhan; Reis, R. L.; Kirkpatrick, C. James; Unger, Ronald E.Presently the majority of tissue engineering approaches aimed at regenerating bone relies only on postimplantation vascularization. Strategies that include seeding endothelial cells (ECs) on biomaterials and promoting their adhesion, migration and functionality might be a solution for the formation of vascularized bone. Nano/micro-fiber-combined scaffolds have an innovative structure, inspired by extracellular ...
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