Encontrados 18 documentos, a visualizar página 1 de 2
Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioen...
Rato, Luis; Duarte, Ana I.; Tomás, Gonçalo D.; Santos, M. S.; Moreira, Paula I.; Socorro, Silvia; Cavaco, José E.; Alves, Marco G.; Oliveira, Pedro F.Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at testicular level. Peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) and Sirtuin 3 (Sirt3) are pivotal inmitochondrial function. We hypothesized that pre-diabetes disrupts testicular PGC-1α/Sirt3 axis, compromising testicular mitochondrial function. Using a high-energy-diet induced pre-diabetic rat model,...
Resveratrol affects differently rat liver and brain mitochondrial bioenergetics...
Moreira, Ana C.; Silva, Ana M.; Santos, M. S.; Sardão, Vilma A.Resveratrol (3,5,40-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondrial fractions fro...
The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced perme...
Silva, Filomena S. G.; Ribeiro, Mariana P. C.; Santos, M. S.; Rocha-Pereira, Petronila; Santos-Silva, Alice; Custódio, José B. A.The combination of isotretinoin (13-cis-retinoic acid) with antiestrogens seems to be a promising strategy for cancer chemotherapy. The aim of the study was to evaluate the effects of isotretinoin alone or in combination with 4-hydroxytamoxifen (OHTAM) and with its prodrug tamoxifen (TAM), on the functions of rat liver mitochondria, i.e., mitochondrial permeability transition (MPT), bioenergetic functions and a...
UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-ter...
Cardoso, Susana; Santos, M. S.; Moreno, A. J. M.; Moreira, Paula I.A growing body of evidence suggests that mitochondrial proton-leak functions as a regulator of reactive oxygen species production and its modulation may limit oxidative injury to tissues. The main purpose of this work was to characterize the proton-leak of brain cortical mitochondria from long-term hyperglycemic and insulininduced recurrent hypoglycemic rats through the modulation of the uncoupling protein 2 (U...
Comparing the performance of different thermoplastic matrix pre-impregnated mat...
Santos, M. S.; Nunes, J. P.; Silva, J. F.; Novo, Paulo; Marques, A. T.This work studies and compares the processability into final composite parts of three different pre-impregnated materials, produced by different wetting techniques. All studied pre-impregnated materials were based on a continuous glass fibers reinforced polypropylene matrix (GF/PP) system. One is a tape produced in a previous work by using the melting process (cross-head extrusion) and, from the other two produ...
Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality...
Biagioni Santos,M.S.; Seguro,A.C.; Andrade,L.The objective of the present study was to determine the prevalence of electrolyte disturbances in AIDS patients developing acute kidney injury in the hospital setting, as well as to determine whether such disturbances constitute a risk factor for nephrotoxic and ischemic injury. A prospective, observational cohort study was carried out. Hospitalized AIDS patients were evaluated for age; gender; coinfection with...
Identification of fungemia agents using the polymerase chain reaction and restr...
Santos,M.S.; Souza,E.S.; Junior,R.M.S.; Talhari,S.; Souza,J.V.B.Prompt and specific identification of fungemia agents is important in order to define clinical treatment. However, in most cases conventional culture identification can be considered to be time-consuming and not without errors. The aim of the present study was to identify the following fungemia agents: Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Cryptococcus neoformans, Cryptoc...
Alkyl deoxy-arabino-hexopyranosides: synthesis, surface properties, and biologi...
Silva, Filipa; Goulart, Margarida; Justino, Jorge; Neves, Ana; Santos, F.; Caio, J.; Lucas, S.; Newton, A.; Sacoto, D.; Barbosa, E.; Santos, M. S.Octyl and dodecyl glycosides possessing 2-deoxy-arabino-hexopyranoside moieties belonging to the D-and L-series in their alpha- and beta-forms were synthesized by reaction of an acetyl protected glycal with octanol or dodecanol, catalyzed by triphenylphosphine hydrobromide, followed by deprotection. Their surface properties were studied and discussed in terms of the adsorption and aggregation parameters, pC(20)...
Bartonella native valve endocarditis: the first brazilian case alive and well
Lamas,C.; Favacho,A.; Ramos,R.G.; Santos,M.S.; Ferravoli,G.I.; Weksler,C.; Rozental,T.; Bóia,M.N.; Lemos,E.R.S.Bartonella is an important cause of blood culture-negative endocarditis in recent studies. Seroprevalence studies in the States of Minas Gerais and Rio de Janeiro have shown Bartonella IgG positivity around 14% in healthy adults and 40% in HIV seropositive adults, respectively. A case report of a 46-year-old white male with moderate aortic regurgitation (AR) due to rheumatic heart disease (RHD), admitted due to...
Pragas e inimigos naturais presentes nas folhas das plantas de feijão-caupi e m...
OLIVEIRA, I. R. DE O.; ANDRADE, L. N. T.; NUNES, M. U. N.; CARVALHO, L. M. de; SANTOS, M. S.2006
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