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Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected wi...
Santos, J.; Gouveia, M.J.; Vale, N.; Delgado, M. de L.; Gonçalves, A.; da Silva, J.M.; Oliveira, C.; Xavier, P.; Gomes, P.; Santos, L.L.; Lopes, C.Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schis...
Recommendations for Mutational Analysis in Gastrointestinal Stromal Tumors (GIS...
Lopes, J M; Faculdade de Medicina do Porto, Serviço de Anatomia Patológica do Centro Hospitalar de S.João, e IPATIMUP, Porto - PortugalGIST Portuguese Working Group – Condeixa ProposalThe authors outline recommendations for the mutational analysis of GISTs unanimously approved by a multidisciplinary group on July 20th, 2062. The mutational status of KIT and PDGFRA allows identifying therapeutic targets to tyrosine kinase inhibitors (TKIs), and therefore, the safe clinical practice in the biotherapy decisions for patients with GISTs should incl...
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