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FASL polymorphism is associated with response to bacillus Calmette-Guérin immun...
Lima, Luís; Ferreira, José Alexandre; Tavares, Ana; Oliveira, Daniela; Morais, António; Videira, Paula; Medeiros, Rui; Santos, LúcioObjective Deregulation of FAS/FASL system may lead to immune escape and influence bacillus Calmette-Guérin (BCG) immunotherapy outcome, which is currently the gold standard adjuvant treatment for high-risk non–muscle invasive bladder tumors. Among other events, functional promoter polymorphisms of FAS and FASL genes may alter their transcriptional activity. Therefore, we aim to evaluate the role of FAS and FASL...
Guidelines for diagnostic and treatment of gastric adenocarcinoma (Digestive Ca...
Brito, Donzília; Especialista em Cirurgia Geral – IPO - Porto - Portugal; Raimundo, Ana; Especialista em Oncologia Médica – IPO - Porto - Portugal. ; .
Evolução técnica em olivicultura
Barroso, João; Peça, José; Dias, António; Pinheiro, Anacleto; Santos, Lúcio“O Grande Livro da Oliveira e do Azeite – Portugal Oleícola”, cujo autor-coordenador foi o Comendador Jorge Bohm, tem inserido no tema “Evolução técnica em olivicultura” o capítulo da evolução técnica em olivicultura, em que são abordados os seguintes aspectos: - Tecnologias culturais; - Mecanização; - Importância da rega no olival - Conceitos e prática. Em cada um dos aspectos anteriores são apresentadas as s...
Response of high-risk of recurrence/progression bladder tumours expressing sial...
Lima, Luís; Severino, Paulo; Silva, Mariana; Miranda, Andreia; Tavares, Ana; Pereira, Sofia; Fernandes, Elisabete; Cruz, Ricardo; Amaro, TeresinaHigh risk of recurrence/progression bladder tumours is treated with Bacillus Calmette-Guérin (BCG) immunotherapy after complete resection of the tumour. Approximately 75% of these tumours express the uncommon carbohydrate antigen sialyl-Tn (Tn), a surrogate biomarker of tumour aggressiveness. Such changes in the glycosylation of cell-surface proteins influence tumour microenvironment and immune responses that m...
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...
Lima, Luís; Oliveira, Daniela; Tavares, Ana; Amaro, Teresina; Cruz, Ricardo; Ferreira, José Alexandre; Santos, LúcioOBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced ...
Ferreira, José Alexandre; Videira, Paula; Lima, Luís; Pereira, Sofia; Silva, Mariana; Carrascal, Milene; Severino, Paulo; Fernandes, ElisabeteLittle is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found ...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Predictive biomarkers of bacillus calmette-guérin immunotherapy response in bla...
Lima, Luís; Ribeiro, Mário Dinis; Longatto Filho, Adhemar; Santos, LúcioThe most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Gu´erin (the BCG vaccine). This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with highgrade tumours, T1 tumours, and in ...
Cuidados Intensivos
Carvalho, Nuno; Costa, Beatriz; Santos, Lúcio Lara.
Aperfeiçoamento de um algoritmo de Estimação de Estados para Rede de Distribuiç...
Santos, Lúcio Miguel Portela dosTese de mestrado integrado. Engenharia Electrotécnica e de Computadores - Major Energia. Faculdade de Engenharia. Universidade do Porto. 2008
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