Encontrados 14 documentos, a visualizar página 1 de 2
EXTENSIVE PYODERMA GANGRENOSUM IN A PATIENT NONADHERENT TO THE TREATMENT
Meotti, Carolina Degen; Especialista em Dermatologia pela Sociedade Brasileira Dermatologia/Dermatologist, Brasilian Society of Dermatology, BrasilThe growth factor receptor inhibitors represent a relative new class of medications which have been often used on oncology to treat various types of neoplasia. Many tegumentary manifestations have been described. On this article, we report a case of 55 year-old-male in use of sunitinib malate to treat metastatic renal carcinoma that developed hypercromic spots, perlèche and palmar erythema. On this report, we d...
C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerev...
Pacheco, Andreia; Azevedo, Flávio; Rego, António; Santos, Júlia; Chaves, S. R.; Côrte-Real, Manuela; Sousa, Maria JoãoSpecific ceramides are key regulators of cell fate, and extensive studies aimed to develop therapies based on ceramide-induced cell death. However, the mechanisms regulating ceramide cytotoxicity are not yet fully elucidated. Since ceramides also regulate growth and stress responses in yeast, we studied how different exogenous ceramides affect yeast cells. C2-phytoceramide, a soluble form of phytoceramides, the...
Ammonium-dependent shortening of CLS in yeast cells starved for essential amino...
Santos, Júlia; Leão, Cecília; Sousa, Maria JoãoAmmonium (NH4(+)) leads to chronological life span (CLS) shortening in Saccharomyces cerevisiae BY4742 cells, particularly evident in cells starved for auxotrophy-complementing amino acids (leucine, lysine, and histidine) simultaneously. Here, we report that the effect of NH4(+) on aging yeast depends on the specific amino acid they are deprived of. Compared with no amino acid starvation, starvation for leucine...
The genome sequence of the highly acetic acid-tolerant zygosaccharomyces bailii...
Leão, Cecília; Rodrigues, Fernando José dos Santos; Santos, Júlia; Mira, Nuno P.; Münsterkötter, Martin; Valada, Filipa Dias; Palma, MargaridaIn this work, it is described the sequencing and annotation of the genome of the yeast strain ISA1307, isolated from a sparkling wine continuous production plant. This strain, formerly considered of the Zygosaccharomyces bailii species, has been used to study Z. bailii physiology, in particular, its extreme tolerance to acetic acid stress at low pH. The analysis of the genome sequence described in this work ind...
Growth culture conditions and nutrient signaling modulating yeast chronological...
Santos, Júlia; Leão, Cecília; Sousa, Maria JoãoThe manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also been implicated in...
Ammonium Is toxic for aging yeast cells, inducing death and shortening of the c...
Santos, Júlia; Sousa, Maria João; Leão, CecíliaHere we show that in aging Saccharomyces cerevisiae (budding yeast) cells, NH4+ induces cell death associated with shortening of chronological life span. This effect is positively correlated with the concentration of NH4+ added to the culture medium and is particularly evident when cells are starved for auxotrophy-complementing amino acids. NH4+-induced cell death is accompanied by an initial small increase of ...
Ammonium toxicity in aging yeast cells reduces chronological life span : cell d...
Santos, JúliaTese de doutoramento em Ciências da Saúde ; Yeast has emerged as one of the most important model organisms to study the environmental and genetic factors affecting longevity and its exploitation has made huge contributions to the progress in understanding aging. Major advances in this research field came from dietary regimes that have been shown to increase longevity in organisms ranging from yeast to mammals....
Vagares da alma : elaborações ameríndias acerca do sonhar
Santos, Júlia Otero dosDissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Sociais, Departamento de Antropologia, Programa de Pós-graduação em Antropologia Social, 2010. ; Essa dissertação versa sobre os significados dos sonhos para alguns povos ameríndios a partir da leitura de etnografias e artigos que abordam de alguma forma o universo onírico. Para diversos povos, os sonhos são o momento de materialização do...
Seroprevalence of hepatitis A immunity among brazilian adult patients with live...
Oliveira,Luiz Carlos Marques de; Comácio,Samantha Martins; Santos,Júlia de Fátima GonçalvesBACKGROUND: Patients with chronic liver disease have a higher risk of fulminant hepatitis when infected with hepatitis A virus, and vaccination of these patients against such infection is recommended. In Brazil, mainly in the South and Southeast regions, the epidemiology of hepatitis A (HA) has shifted from high to intermediate endemicity, which would have implication on policy of HA vaccination for these popul...
Ammonium blocks chronological lifespan extension of extreme calorie restriction...
Santos, Júlia; Sousa, Maria João; Leão, CecíliaWe have previously shown that ammonium stimulates cell death in amino acid-deprived auxotrophic cells of Saccharomyces cerevisiae (aa-starved cells) transferred to water, whereas the same cells in absence of ammonium displayed chronological lifespan (CLS) expansion typical of extreme starvation conditions. The enhanced loss of cell viability in the presence of ammonium was accompanied by an initial small increa...
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