Encontrados 11 documentos, a visualizar página 1 de 2
Temporal changes in Neutral Endopeptidase/CD10 immunoexpression in the cyclic a...
Payan-Carreira, Rita; Santos, Celso; Miranda, Sónia; Neto Pereira, Rosa L.; Santos, Dario; Pires, Maria dos AnjosCD10 is a multifunctional transmembrane neutral endopeptidase (NEP), considered to be a reliable marker of ectopic human endometrial stroma. Available information in NEP/CD10 protein expression in animal endometria is scarce. This study focused on the immunolocalization of NEP/CD10 in the canine uterus and on its temporal changes during the oestrous cycle and early pregnancy (days 11 to 23 post-LH surge) in hea...
Cover crops for the sustainability of rainfed olive orchards
Bacelar, Eunice; Correia, Carlos; Santos, Dario; Moutinho-Pereira, José; Gonçalves, Berta; Brito, Cátia; Ferreira, Helena; Rodrigues, ÂngeloOlive tree (Olea europaea L.) is present in large areas of mainland Portugal, predominantly in less-favored regions. In spite of the fact that irrigated areas are currently increasing, most of the olive orchards are still cultivated under rainfed conditions. The success of olive farming under rainfed conditions is mainly due to the high capacity of olive tree to develop anatomical, physiological and biochemical...
Fitoquímicos presentes em frutos silvestres
Azevedo, Maria M.; Santos, Dario J. L.; Silva, Amélia M.Os frutos silvestres, nomeadamente a amora, o arando vermelho, a framboesa, o mirtilo e a baga de sabugueiro, são particularmente ricos em fitoquímicos (e.g., flavonóides, taninos, polifenóis e ácidos fenólicos) cuja acção biológica se relaciona com protecção antioxidante, cardiovascular, acção anti-envelhecimento e anti-cancerígena. A obtenção de extractos purificados, a sua caracterização química e a elucidaç...
Prenatal administration of vitamin A alters pulmonary and plasma levels of vasc...
Pinto, Maria de Lurdes; Rodrigues, Paula; Coelho, Ana Cláudia; Pires, Maria dos Anjos; Santos, Dario Loureiro dos; Gonçalves, CarlosVitamin A and the retinoids play a unique role in mammalian embryonic and foetal development and are essential for both cellular differentiation and the establishment of normal morphogenesis. Vascular endothelial growth factor (VEGF) is a known potent mitogenic factor that plays a key role in lung development and function maintenance. In order to contribute to a better knowledge of the modulating effects of vit...
Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mi...
Oliveira, Paulo J.; Seica, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardao, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The objective of this ...
Diabetes and mitochondrial oxidative stress: A study using heart mitochondria f...
Santos, Dario Loureiro; Palmeira, Carlos Marques; Seiça, Raquel; Dias, José; Mesquita, José; Moreno, Antonio Joaquim; Santos, Maria SanchaIncreasing evidence shows that the overproduction of reactive oxygen species, induced by diabetic hyperglycemia, contributes to the development of several cardiopathologies. The susceptibility of diabetic hearts to oxidative stress, induced in vitro by ADP-Fe2+ in mitochondria, was studied in 12-month-old Goto-Kakizaki rats, a model of non-insulin dependent diabetes mellitus, and normal (non-diabetic) Wistar ra...
Inhibitory effect of carvedilol in the high-conductance state of the mitochondr...
Oliveira, Paulo J.; Coxito, Pedro M.; Rolo, Anabela P.; Santos, Dario L.; Palmeira, Carlos M.; Moreno, António J. M.The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane, and that opening of this pore is the cause of some forms of mitochondrial dysfunction. In this work, we propose that carvedilol, a multi-role cardioprotective c...
Inhibition of heart mitochondrial lipid peroxidation by non-toxic concentration...
Santos, Dario J. S. L.; Moreno, António J. M.Carvedilol, a non-selective [beta]-adrenoreceptor blocker, has been shown to possess a high degree of cardioprotection in experimental models of myocardial damage. Reactive oxygen species have been proposed to be implicated in such situations, and antioxidants have been demonstrated to provide partial protection to the reported damage. The purpose of our study was to investigate the antioxidant effect of carved...
Brain and liver mitochondria isolated from diabeticGoto-Kakizaki rats show diff...
Santos, Maria S.; Santos, Dario L.; Palmeira, Carlos M.; Seiça, Raquel; Moreno, António J.; Oliveira, Catarina R.Increased oxidative stress and changes in antioxidant capacity observed in both clinical and experimental diabetes mellitus have been implicated in the etiology of chronic diabetic complications. Many authors have shown that hyperglycemia leads to an increase in lipid peroxidation in diabetic patients and animals reflecting a rise in reactive oxygen species production. The aim of the study was to compare the su...
Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabeti...
Palmeira, Carlos M.; Santos, Dario L.; Seiça, Raquel; Moreno, António J.; Santos, Maria S.Because diabetes mellitus is associated with impairment of testicular function, ultimately leading to reduced fertility, this study was conducted to evaluate the existence of a cause-effect relationship between increased oxidative stress in diabetes and reduced mitochondrial antioxidant capacity. The susceptibility to oxidative stress and antioxidant capacity (in terms of glutathione, coenzyme Q, and vitamin E ...
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