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High resolution crystal structures of piscine transthyretin reveal different bi...
Eneqvist, Therese; Lundberg, Erik; Karlsson, Anders; Huang, Shenghua; Santos, Cecília R. A.; Power, Deborah; Sauer-Eriksson, A. ElisabethTransthyretin (TTR) is an extracellular transport protein involved in the distribution of thyroid hormones and vitamin A. So far, TTR has only been found in vertebrates, of which piscine TTR displays the lowest sequence identity with human TTR (47%). Human and piscine TTR bind both thyroid hormones 3,5,3 -triiodo- L-thyronine (T3) and 3,5,3 ,5 -tetraiodo-L-thyronine (thyroxine, T4). Human TTR has higher affinit...
Cloning, characterization, and tissue distribution of prolactin receptor in the...
Santos, Cecilia R. A.; Ingleton, P. M.; Cavaco, J. E. B.; Kelly, P. A.; Edery, M.; Power, DeborahThe prolactin receptor (PRLR) was cloned and its tissue distribution characterized in adults of the protandrous hermaphrodite marine teleost, the sea bream (Sparus aurata). An homologous cDNA probe for sea bream PRLR (sbPRLR) was obtained by RT-PCR using gill mRNA. This probe was used to screen intestine and kidney cDNA libraries from which two overlapping clones (1100 and 2425 bp, respectively) were obtained.
Identification of transthyretin in fish (Sparus aurata) cDNA cloning and charac...
Santos, Cecília R. A.; Power, DeborahTransthyretin (TTR) has been proposed to have first evolved in reptiles and is one of the three plasma proteins important in the transport of thyroid hormones in higher vertebrates.
Piscine (Sparus aurata) transthyretin cDNA cloning and characterization
Santos, Cecília R. A.; Power, DeborahTransthyretin (TTR) is one of the three plasma proteins that participate in the transport of thyroid hormones, thyroxine (T4) and triiodothyronine (T3); it is also involved in the carriage of retinol through the mediation of retinol-binding protein.1 The liver and choroid plexus are the major sites of TTR synthesis in mammals, birds, and diprotodont marsupials; in reptiles, TTR is only synthesized in the choroi...
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