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The combination of glutamate receptor antagonist MK-801 with tamoxifen and its ...
Ribeiro, Mariana P. C.; Nunes-Correia, Isabel; Santos, Armanda E.; Custódio, José B. A.Recent reports suggest that N-methyl-d-aspartate receptor (NMDAR) blockade by MK-801 decreases tumor growth. Thus, we investigated whether other ionotropic glutamate receptor (iGluR) antagonists were also able to modulate the proliferation of melanoma cells. On the other hand, the antiestrogen tamoxifen (TAM) decreases the proliferation of melanoma cells, and is included in combined therapies for melanoma. As t...
Differential postreceptor signaling events triggered by excitotoxic stimulation...
Santos, Armanda E.; Carvalho, Ana L.; Lopes, Maria C.; Carvalho, Arsélio P.The aim of this work was to investigate whether excitotoxicity induced by overstimulation of different ionotropic glutamate receptors could trigger different intracellular signaling cascades. Cultured chick neuronal retina cells, essentially amacrine-like, were particularly sensitive to the toxicity induced by non-NMDA glutamate receptor agonists. One hour stimulation with 100 muM kainate induced a reduction of...
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