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Cox-2 inhibition with nutraceuticals: a new therapeutic approach against Helico...
Santos, António Mário; Oleastro, Mónica; Lopes, Teresa; Pereira, Teresa; Seixas, Elsa; Chaves, Paula; Machado, Jorge; Guerreiro, António SousaAbstract no.: P3.7 publicado em: Helicobacter 2012;17(Suppl.1):98 ; Accumulated evidence in humans and animals shows that H. pylori up-regulate the expression of cyclooxygenase (COX)-2 both at mRNA and protein levels which might be one of the mechanisms leading to several gastric diseases. Aim: To study the expression of COX-2 on mice gastric mucosa during long-term treatment with two nutraceuticals: curcumin ...
Nutraceuticals: a new therapeutic approach against
Santos, António Mário; Oleastro, Mónica; Vale de Gato, Inês; Lopes, Teresa; Seixas, Elsa; Machado, Jorge; Guerreiro, António SousaBackground and Aim: H. pylori induces severe gastric chronic inflammation and is the cause of gastritis, peptic ulcer and a major risk factor for gastric cancer. The aim of the study was to investigate the anti-inflammatory effect of two nutraceuticals in Hp-infected mucosa. Materials and Methods: Eighteen C57BL/6 mice were inoculated with Hp SS1 by gavage three times with 3 · 109 viable cells. Mice were then t...
Evaluation of invasive and non-invasive methods for the diagnosis of Helicobact...
Ogata,Silvio Kazuo; Kawakami,Elisabete; Patrício,Francy Reis Silva; Pedroso,Margareth Zabeu; Santos,Antonio MarioCONTEXT: Multiple diagnostic methods are available for the detection of Helicobacter pylori infection, but at present no single one can be used as the gold standard. OBJECTIVE: The aim of this study was to evaluate the diagnostic accuracy of 3 invasive and 2 non-invasive methods for detection of Helicobacter pylori infection in symptomatic children and adolescents. DESIGN: Prospective cohort study SETTING: Pept...
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