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Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Controlled release strategies for bone, cartilage, and osteochondral engineerin...
Santo, Vitor E.; Gomes, Manuela E.; Mano, J. F.; Reis, R. L.The potential of growth factors to stimulate tissue healing through the enhancement of cell proliferation, migration, and differentiation is undeniable. However, critical parameters on the design of adequate carriers, such as uncontrolled spatiotemporal presence of bioactive factors, inadequate release profiles, and supraphysiological dosages of growth factors, have impaired the translation of these systems ont...
Magnetic nanoparticles potential for stem cell functionalization
Gonçalves, A. I.; Rodrigues, Márcia T.; Santo, Vítor E.; Reis, R. L.; Gomes, Manuela E.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Stem cells have the capacity to migrate within tissues to damaged areas. The ability to remotely monitor and manipulate cells encouraging their precise positioning to desired sites for tissue regeneration would have a potential impact in tissue engineering and regenerative medicine. Cell monitoring and cell localiz...
Magnetic-responsive hydrogels for cartilage tissue engineering
Popa, Elena G.; Rodrigues, Márcia T.; Santo, Vítor E.; Gonçalves, A. I.; Reis, R. L.; Gomes, Manuela E.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The use of magnetic nanoparticles (MNPs) has been explored as an alternative approach to overcome current limitations of regenerative medicine strategies. Cell engineering approaches where MNPs are incorporated within three-dimensional constructs, such as scaffolds or hydrogels may constitute a novel and attractive...
Platelets lysate-based membranes for periodontal ligament regeneration
Babo, P. S.; Santo, Vítor E.; Duarte, Ana Rita C.; Gomes, Manuela E.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The periodontal ligament (PDL) is a group of specialized connective tissue fibers that attach a tooth to the alveolar bone where it is deployed. These fibers help the tooth withstand the substantial compressive forces which occur during chewing and remain embedded in the bone. Periodontitis is a prevalent infection...
Development of bioactive constructs through cell crosslinking for tissue regene...
Custódio, Catarina A.; Santo, Vitor E.; Gomes, Manuela E.; Reis, R. L.; Mano, J. F.Injectable systems are particularly attractive for a minimally invasive approach in tissue engineering applications. Many different methods for in situ crosslinking have been investigated however the ability of cells to promote hydrogel formation has not been fully explored. This study addressed the hypothesis that cells can promote crosslinking of chitosan microparticles forming a tridimensional network. Throu...
Platelet lysates scaffolds prepared by supercritical fluid technology as autolo...
Duarte, Ana Rita C.; Santo, Vitor E.; Gomes, Manuela E.; Mano, J. F.; Reis, R. L.The tissue engineering strategy proposed in this work regards the development of a novel autologous scaffold based on platelet lysates (PLs) with the ultimate goal of promoting the regeneration of an orthopaedic osteochondral interface. PLs are a high concentration of platelets in a small volume of plasma that, when activated, release several growth factors (GFs). Most of current PLs-based hydrogels present sev...
Modulation of adipose tissue derived stem cells encapsulated in injectable mult...
Coutinho, Daniela F.; Santo, Vitor E.; Caridade, S. G.; Mano, J. F.; Gomes, Manuela E.; Neves, N. M.; Reis, R. L.Objective : The cellular microenvironment plays an important role in controlling the cellular behavior. Therefore, in Tissue Engineering strategies, systems have been designed so that by combining cells, signaling molecules and engineered substrates, one can mimic as closely as possible the native microenvironment of the extracellular matrix. In this context, injectable hydrogels have been developed that allow ...
In vitro and in vivo biocompatibility evaluation of k-carrageenan hydrogels aim...
Popa, Elena G.; Carvalho, P. P.; Dias, A. F.; Santo, Vitor E.; Frias, A. M.; Marques, A. P.; Dias, Isabel R.; Viegas, Carlos A.; Gomes, Manuela E.Introduction The development of biomaterials for biomedical applications always requires extensive biological testing to demonstrate the safety of both the material and its degradation components. K-carrageenan is a naturally occurring polysaccharide which forms a hydrogel with potassium ions and the temperature-induced gelation enables its application as an in vitro cell-carrier or as an in vivo injectable sys...
Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin s...
Santo, Vitor E.; Duarte, Ana Rita C.; Gomes, Manuela E.; Mano, J. F.; Reis, R. L.In the tissue engineering (TE) field, the concept of producing multifunctional scaffolds, capable not only of acting as templates for cell transplantation but also of delivering bioactive agents in a controlled manner, is an emerging strategy aimed to enhance tissue regeneration. In this work, a complex hybrid release system consisting in a three-dimensional (3D) structure based on poly(d,l-lactic acid) (PDLLA)...
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