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In vivo biofunctional evaluation of hydrogels for disc regeneration

Reitmaier, Sandra; Kreja, Ludwika; Gruchenberg, Katharina; Kanter, Britta; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Perugini, V.

Purpose Regenerative strategies aim to restore the original biofunctionality of the intervertebral disc. Different biomaterials are available, which might support disc regeneration. In the present study, the prospects of success of two hydrogels functionalized with anti-angiogenic peptides and seeded with bone marrow derived mononuclear cells (BMC), respectively, were investigated in an ovine nucleotomy model. ...


Functionalisation of methacrylated gellan gum hydrogels by anti-angiogenic dend...

Perugini, V.; Silva-Correia, J.; Oliveira, Joaquim M.; Meikle, S. T.; Guildford, A. L.; Reis, R. L.; Santin, M.

The regeneration of cartilage in the intervertebral disc nucleus pulposus and joints is impaired by the formation of fibrocartilage that is caused by the invasion of the tissue by blood vessels. Peptides have been identified by phage display technique which are able to bind VEGF thus inhibiting angiogenesis. The present works focusses on the synthesis of poly(epsilon-lysine) dendrons of three branching generati...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia