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Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad
Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Fernando José dos Santos; Ludovico, PaulaAutophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation...
Anatypical active cell death process underlies the fungicidal activity of ciclo...
Almeida, Bruno; Sampaio-Marques, Belém; Carvalho, Joana; Silva, Manuel T.; Leão, Cecília; Rodrigues, Fernando José dos Santos; Ludovico, PaulaCiclopirox olamine (CPO), a fungicidal agent widely used in clinical practice, induced in Saccharomyces cerevisiae an active cell death (ACD) process characterized by changes in nuclear morphology and chromatin condensation associated with the appearance of a population in the sub-G0/G1 cell cycle phase and an arrest in the G2/M phases. This ACD was associated neither with intracellular reactive oxygen species ...
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