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Differentiation of mesenchymal stem cells in chitosan scaffolds with double mic...
Garcia Cruz, Dunia M.; Gomes, Manuela E.; Reis, R. L.; Moratal, David; Salmerón-Sánchez, M.; Gómez Ribelles, J. L.; Mano, J. F.Bone Marrow mesenchymal stem cells can be induced to differentiate into osteoblasts to regenerate damaged bone tissue using tissue engineering techniques. In this study, we examine the use of chitosan scaffolds with double pore structure prepared by an innovative method that combines freeze gelation (that produces micropores) and particle leaching out technique (that produces interconnected spherical macropores...
Proliferation and differentiation of goat bone marrow stromal cells in 3d scaff...
Escobar Ivirico, J. L.; Salmerón-Sánchez, M.; Gómez Ribelles, J. L.; Monleón Pradas, M.; Soria, Jose Miguel; Gomes, Manuela E.; Reis, R. L.; Mano, J. F.We have synthesized methacrylate-endcapped caprolactone networks with tailored water sorption ability, poly(CLMA-co-HEA), in the form of three-dimensional (3D) scaffolds with the same architecture but exhibiting different hydrophilicity character (xHEA50, 0.3, 0.5), and we investigated the interaction of goat bone marrow stromal cells (GBMSCs) with such structures. For this purpose, GBMSCs were seeded and cultu...
Chitosan microparticles as injectable scaffolds for tissue engineering
Garcia Cruz, Dunia M.; Escobar Ivirico, J. L.; Gomes, Manuela M.; Gómez Ribelles, J. L.; Salmerón-Sánchez, M.; Reis, R. L.; Mano, J. F.The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the mor...
Glass transition dynamics and structural relaxation of PLLA studied by DSC : In...
Mano, J. F.; Gómez Ribelles, J. L.; Alves, N. M.; Salmerón-Sánchez, M.Poly(L-lactic acid), PLLA, in amorphous and semi-crystalline forms were studied by DSC, in order to investigate both molecular dynamics and structural relaxation features, and to understand the influence of the crystalline confinement on the segmental mobility of the intraspherulitic amorphous phase. Experimental data were generated after submitting the materials to different thermal histories below Tg and were...
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