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Fluorescence in situ hybridization method using peptide nucleic acid probes for...

Background: Bacterial vaginosis (BV) is a common vaginal infection occurring in women of reproductive age. It is widely accepted that the microbial switch from normal microflora to BV is characterized by a decrease in vaginal colonization by Lactobacillus species together with an increase of Gardnerella vaginalis and other anaerobes. Our goal was to develop and optimize a novel Peptide Nucleic Acid (PNA) Fluore...

Asymmetric diels-alder reaction of tert-butyl 2H-azirine-3-carboxylate by a se...

Diastereo-selectivity of diels-alder cycloaddtions of erythrose benzylidene-ace...

Diastereo-selectivity in diels–alder cycloadditions of erythrose benzylidene-ac...

Maleimides were combined with D-erythrose benzylidene-acetal 1,3-butadienes 1 and 2 to study the facial selectivity of the Diels-Alder cycloadditions. The selectivity was found to be from moderate to good. The reaction diastereotopicity can be reversed with the temperature. Simultaneous coordination of diene 1, having a free hydroxyl group, and maleimide 3 to a chiral bimetallic Lewis acid catalyst (LACASA-DA r...

Diels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and deriv...

This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of deri...

Presence of Gardnerella vaginalis in healthy portuguese women : a pilot study

Bacterial vaginosis (BV) has an important position worldwide, as the leading vaginal disorder in women, and affects 30-50% of African women and 10-20% of White women of reproductive age. This condition although not mortal causes great discomfort and may lead to other complications such as pre-term labour or increase susceptibility for HIV infection. During BV occur a decrease of Lactobacillus spp. present in t...

The synthesis of an homochiral aziridine as a useful synton to iminosugars and ...

Synthesis of 1-azafagomine analog and 1-N-phenyl carboxamide 1-azafagomine cont...

A concise synthesis of 8a-epi-swaisonine analogue