Encontrados 39 documentos, a visualizar página 1 de 4
De novo bone formation on macro/microporous silk and silk/nano-sized calcium ph...
Yan, Leping; Salgado, A. J.; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.Macro/micro porous silk/nano-sized calcium phosphate scaffolds (SC16) with bioactive and superior physicochemical properties have been recently developed. In this study, we aim at evaluating the new bone formation ability of the SC 16 scaffolds in vivo, using silk fibroin scaffolds (S16) as control. The CaP distribution profile in the scaffolds was characterized by Micro-Computed Tomography. The in vitro minera...
Benefits of spine stabilization with biodegradable scaffolds in spinal cord inj...
Silva, Nuno; Sousa, R. A.; Fraga, J. S.; Fontes, Marco; Almeida, Hugo Leite; Cerqueira, R.; Almeida, Armando; Sousa, Nuno; Reis, R. L.; Salgado, A. J.Spine stabilization upon spinal cord injury (SCI) is a standard procedure in clinical practice, but rarely employed in experimental models. Moreover, the application of biodegradable biomaterials for this would come as an advantage as it would eliminate the presence of a nondegradable prosthesis within the vertebral bone. Therefore, in the present work, we propose the use of a new biodegradable device specifica...
Mesenchymal stem cells secretome : a new paradigm for Central Nervous System Re...
Teixeira, F. G.; Carvalho, M. M.; Sousa, N.; Salgado, A. J.The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already dem...
Mesenchymal stem cells secretome : a new paradigm for central nervous system re...
Teixeira, F. G.; Carvalho, Miguel M.; Sousa, Nuno; Salgado, A. J.The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already dem...
Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Silva, Nuno; Rodrigues, Ana João; Sousa, Nuno; Salgado, A. J.; Fraga, J. S.; Reis, R. L.; Manadas, B.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Regeneration strategies in the central nervous system : drug-loaded nanoparticl...
Cerqueira, Susana R.; Oliveira, Joaquim M.; Mano, J. F.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.Unlike fish, amphibia and even mammalial peripheral nerves, human central nervous system (CNS) axons have a very limited regeneration capability and do not spontaneously re-grow if lesioned. After damage or disruption, for instance caused by brain/ spinal cord injury (SCI) or stroke, a cascade of cellular and biochemical reactions occurs around the lesion site that creates a harsh environment for axons to regen...
Combining adult stem cells and olfactory ensheating cells : the secretome effect
Silva, Nuno; Sousa, Nuno; Salgado, A. J.Adipose-derived adult stem cells (ASCs), bone marrow mesenchymal stem cells (bmMSCs), and human umbilical cord perivascular cells (HUCPVCs) tissue have been widely tested for regenerative applications, such as bone regeneration. Moreover, olfactory ensheathing cells (OECs) show promise in promoting spinal cord injury (SCI) regeneration. Our group recently proposed the use of a hybrid scaffold targeting both ver...
Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Fraga, J. S.; Silva, N. A.; Lourenço, A. S.; Gonçalves, V.; Neves, N. M.; Reis, R. L.; Rodrigues, A. J.; Manadas, B.; Sousa, N.; Salgado, A. J.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Interactions between Schwann and olfactory ensheathing cells with a starch/poly...
Silva, Nuno; Sousa, R. A.; Pires, Ana; Sousa, Nuno; Salgado, A. J.; Reis, R. L.Spinal cord injury (SCI) represents a major world health problem. Therefore it is urgent to develop novel strategies that can specifically target it. We have previously shown that the implantation of starch-based scaffolds (SPCL) aimed for spine stabilization on SCI animals leads to motor skills improvements. Therefore, we hypothesize that the combination of these scaffolds with relevant cell populations for SC...
Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles i...
Cerqueira, Susana R.; Oliveira, Joaquim M.; Silva, Barbara L.; Silva, N. A.; Mano, J. F.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.Spinal cord injuries (SCI) still remain a major challenge in current biomedical research. In spite of several advances in the understanding of its mechanisms there has not been an equal significant translation into the clinics. As a result, there is no effective treatment that can overcome the biochemical and cellular adverse reactions that lead to a chronic severely impaired condition. One of the first opportu...
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