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Sintomas do trato digestivo superior e distúrbios motores do esôfago em pacient...
Sanchez-Lermen,Rafaela de Liz P.; Dick,Eduardo; Salas,José Augusto Pádua; Fontes,Cor Jesus FernandesO estudo descreve os sintomas referidos por portadores da forma indeterminada da doença de Chagas crônica e avalia sua associação com alterações da motilidade esofágica. Manometria do esôfago foi realizada em 50 pacientes, medindo-se a extensão e a pressão do esfíncter inferior do esôfago, o peristaltismo e a amplitude de contração do corpo esofágico. Oito (16%) pacientes apresentaram relaxamento parcial do esf...
African swine fever virus p37 structural protein is localized in nuclear foci c...
Eulálio, Ana; Nunes-Correia, Isabel; Salas, José; Salas, Maria L.; Simões, Sergio; Pedroso de Lima, Maria C.The replication of African swine fever virus DNA is initiated inside the nucleus of host cells, being followed by a longer cytoplasmic replication stage. In face of previous results demonstrating the nucleo-cytoplasmic shuttling activity of ASFV p37 structural protein when considered isolated from the virus infection, we performed a systematic analysis of the subcellular localization of p37 protein in ASFV-infe...
Nuclear export of African swine fever virus p37 protein occurs through two dist...
Eulálio, Ana; Nunes-Correia, Isabel; Carvalho, Ana Luísa; Faro, Carlos; Citovsky, Vitaly; Salas, José; Salas, Maria L.; Simões, SérgioNucleocytoplasmic shuttling activity of the African swine fever virus p37 protein, a major structural protein of this highly complex virus, has been recently reported. The systematic characterization of the nuclear export ability of this protein constituted the major purpose of the present study. We report that both the N- and C-terminal regions of p37 protein are actively exported from the nucleus to the cytop...
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