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Release profile of ibuprofen in β-cyclodextrin complexes from two different sol...
Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Cabral-Marques, Helena; Costa, Paulo; Pinto, JoãoThe objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with β-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion ...
Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral contr...
Salústio, Paulo José; Pontes, Patrícia; Conduto, Cláudia; Sanches, Inês; Carvalho, Catarina; Arrais, João; Cabral Marques, Helena MCyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug or drug-additiv...
Comparison of ibuprofen release from minitablets and capsules containing ibupro...
Salústio, Paulo; Marques, Helena Cabral; Costa, Paulo; Pinto, JoãoNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A def...
Stability and enzymatic studies with omeprazole: hydroxypropyl-β-cyclodextrin
Ramos, Margarida; Salústio, Paulo; Serralheiro, Luísa; Frazão, Fátima; Marques, HelenaThe original publication is available at www.springerlink.com. A publicação original está disponível em www.springerlink.com ; Omeprazole (OME) exhibits low stability to light, heat and humidity. In stress conditions OME stability should improve under inclusion complex form with hydroxypropyl-b-cyclodextrin (HPbCD). Stability of OME, its physical mixture (PM) with HPbCD and OME:HPbCD inclusion complex was asse...
Promoção do aumento da solubilidade de fármacos pouco solúveis para a sua admin...
Salústio, Paulo José Pinto, 1962-Tese de doutoramento, Farmácia (Tecnologia Farmacêutica), 2009, Universidade de Lisboa, Faculdade de Farmácia ; Disponível no documento
The influence of the preparation methods on the inclusion of model drugs in a β...
Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Pinto, João; Marques, Helena CabralNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A def...
Teoria da percolação aplicada à produção de comprimidos
Salústio, Paulo José PintoDissertação de Mestrado em Tecnologia Farmacêutica, área de especialização em Farmacotecnia, apresentada à Faculdade de Farmácia da Universidade do Porto
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