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Biomimetic Ca-P coatings Incorporating bisphosphonates produced on starch-based...
Oliveira, A. L.; Pedro, A. J.; Saiz-Arroyo, C.; Mano, J. F.; Rodriguez, G.; Roman, J. San; Reis, R. L.In this study, sodium clodronate, a well-known therapeutic agent from the family of bisphosphonates (BPs), is incorporated in a biomimetic calcium phosphate (CaP) coating, previously formed on the surface of a starch-based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration applications. The effects on the resulting CaP coating...
Microhardness of starch based biomaterials in simulated physiological conditions
Alves, N. M.; Saiz-Arroyo, C.; Rodriguez-Perez, M. A.; Reis, R. L.; Mano, J. F.In this work the variation of the surface mechanical properties of starch-based biomaterials with immersion time was followed using microhardness measurements. Two blends with very distinct water uptake capabilities, starch/cellulose acetate (SCA) and starch/poly- (e-caprolactone) (SPCL), were immersed in a phosphate buffer solution (PBS) at 37.5 C for various times. The microhardness of the blends decreased s...
In vitro monitoring of surface mechanical properties of poly(L-lactic acid) usi...
Saiz-Arroyo, C.; Wang, Y.; Rodriguez-Perez, M. A.; Alves, N. M.; Mano, J. F.Poly(L-lactic acid) (PLLA) was immersed in a simulated body fluid (SBF) solution at 37.58C for distinct times. The variation of the surface mechanical properties of PLLA samples with immersion time was followed by microhardness. These measurements showed that PLLA microhardness decreased significantly ( 60%) after only 30 days of immersion. The results were explained in terms of hydrolytic degradation of the s...
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