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The role of some folk medicinal herbs and phytochemicals on hepatic lipid metab...
Sá, Carla M.; Lima, Cristóvão F.; Wilson, Cristina PereiraType 2 diabetes mellitus (T2DM) is associated with elevated triglycerides (TG) and LDL levels and decreased HDL levels, a pattern also recognized as dyslipidemia. Although the molecular mechanisms underlying diabetic dyslipidemia are not completely understood, this lipoprotein pattern is associated with T2DM and increased risk of Cardiovascular diseases (CVD). Accumulation of fatty acids and lipid metabolites c...
Cellular distribution and regulation of intestinal SGLT1
Sá, Carla M.; Azevedo, Marisa; Lima, Cristóvão F.; Wilson, Cristina PereiraDiabetes is achieving epidemic proportions in many countries. In addiction to high blood glucose it is associated with increased intestinal expression of the sodium-glucose cotransporter (SGLT1). This transporter is located in brush-border membrane (BBM) of the enterocytes and is responsible for transporting glucose and galactose from the intestinal lumen into the cytosol, using the inward Na+ gradient maintain...
Effects of natural compounds in lipid profile and metabolism in hepatocytes
Sá, Carla M.; Lima, Cristóvão F.; Wilson, Cristina PereiraType 2 diabetes mellitus (T2DM) is associated with elevated triglycerides (TG) and LDL levels and decreased HDL levels, a pattern also recognized as dyslipidemia. Although the molecular mechanisms underlying diabetic dyslipidemia are not completely understood, this lipoprotein pattern is associated with T2DM and increased risk of Cardiovascular diseases (CVD). Accumulation of fatty acids and lipid metabolites c...
Ursolic acid and luteolin-7-glucoside improves rat plasma lipid profile and inc...
Azevedo, Marisa; Camsari, Çagri; Sá, Carla M.; Lima, Cristóvão F.; Ferreira, Manuel Fernandes; Wilson, Cristina PereiraDocumento submetido para revisão pelos pares. A publicar em Phytotherapy Research. ISSN 0951-418X ; In the present study, two phytochemicals – ursolic acid (UA) and luteolin-7-glucoside (L7G) – were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profi le (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes ...
Sage tea drinking improves lipid profile and antioxidant defences in Humans
Sá, Carla M.; Ramos, Alice A.; Azevedo, Marisa; Lima, Cristóvão F.; Ferreira, Manuel Fernandes; Wilson, Cristina PereiraSalvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expressio...
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