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Tubulointerstitial Nephritis and Uveitis Syndrome with non Caseating Granuloma ...

The Tubulointerstitial Nephritis and Uveitis syndrome is a very rare condition, probably under-diagnosed in clinical practice. It ischaracterized by the combination of an interstitial nephritis and uveitis, and is an exclusion diagnosis. Tissue non caseating granuloma can be rarely present, with only 6 cases reported on bone marrow. We present a case of a 55 year old female with a 3-month history of asthenia an...

Docking studies in target proteins involved in mechanisms of antibacterial acti...

In the present work, the knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, inhibitors of nucleic acids synt...

ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA an...

Human ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, and some of these ...

O forno cerâmico da Correlhã : Ponte de Lima

Differential Ole e 1 Release from Olea Airborne Pollen in the Southwest Iberian...

Background: Ole e 1 is the major allergen of olive pollen (Olea europaea L.), the second largest cause of pollinosis in some areas from the Mediterranean Region. Although it has been assumed that airborne pollen is a representative parameter for allergen exposure, variability of allergen content and/or release from pollen has been demonstrated for other taxa. The aim of this study was to: i) estimate the correl...

Grass Pollen Count and Grass group 5-allergen Release across Eight European Cou...

Background: Grass pollen is considered to be the most important outdoor aeroallergen in Europe. The grass ‘pollen count’ is usually used as a proxy for exposure. However, HIALINE has shown that the birch and olive pollen count is not always congruent with allergen concentrations. We therefore simultaneously measured daily exposure to grass pollen and the concentration of group 5 major allergens across eight cou...

The use of lean tools to improve the performance of an elevators company

This paper presents a project developed in an elevators company, in the framework of a master thesis at University of Minho. The main objective of this work was to analyse the production system of one assembly section of the company and to implement some proposals that would improve its performance. This objective was achieved by applying Lean Production tools and techniques namely, 5S, Visual Management and St...

An industrial application of the SMED methodology and other lean production tools

This paper describes the improvement of the setup process of a mechanical press machine in the metal-mechanic area of an elevators company. The work results from a master thesisc project conducted during a period of five months. The Single-Minute Exchange of Die (SMED) methodology and other Lean Production tools (5S, Visual Management and Standard Work) were applied to reduce the setup times observed at the beg...

Spinal infection : state of the art and management algorithm

Spinal infection is a rare pathology although a concerning rising incidence has been observed in recent years. This increase might reflect a progressively more susceptible population but also the availability of increased diagnostic accuracy. Yet, even with improved diagnosis tools and procedures, the delay in diagnosis remains an important issue. This review aims to highlight the importance of a methodological...

Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2...