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Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidam...
Bandarra, S; Fernandes, AS; Magro, I; Guerreiro, PS; Pingarilho, M; Churchwell, MI; Gil, OM; Batinic-Haberle, I; Gonçalves, S; Rueff, J; Miranda, JPAcrylamide (AA) is a well-known industrial chemical classified as a probable human carcinogen. Benign and malignant tumours at different sites, including the mammary gland, have been reported in rodents exposed to AA. This xenobiotic is also formed in many carbohydrate-rich foods prepared at high temperatures. For this reason, AA is an issue of concern in terms of human cancer risk. The epoxide glycidamide (GA)...
Development of pyridine-containing macrocyclic copper(II) complexes: potential ...
Fernandes, A. S.; Costa, J.; Gaspar, J.; Rueff, J.; Cabral, M. F.; Cipriano, M.; Castro, M.; Oliveira, N. G.The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...
Role of haemoglobin in the protection of cultured lymphocytes against diepoxybu...
PORTO, B.; CHIECCHIO, L.; GASPAR, J.; FABER, A.; PINHO, L.; RUEFF, J.; MALHEIRO, I.Mutat Res. 2003 Apr 20;536(1-2):61-7. Role of haemoglobin in the protection of cultured lymphocytes against diepoxybutane (DEB), assessed by in vitro induced chromosome breakage. Porto B, Chiecchio L, Gaspar J, Faber A, Pinho L, Rueff J, Malheiro I. Laboratory of Cytogenetics, Instituto Ciências Biomédicas Abel Salazar (ICBAS), Largo do Prof. Abel Salazar, No. 2, 4099-003, Porto, Portugal. Abstract Diepoxybu...
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