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A stable liquid–liquid extraction system for clavulanic acid using polymer-base...

Pereira, Jorge F. B.; Santos, Valéria Carvalho; Johansson, Hans-Olof; Teixeira, J. A.; Pessoa Junior, Adalberto

The partitioning of Clavulanic Acid (CA) in a novel inexpensive and stable aqueous two-phase system (ATPS) composed by poly(ethylene glycol) (PEG) and sodium polyacrylate (NaPA) has been studied. The aqueous two-phase systems are formed by mixing both polymers with a salt (NaCl or Na2SO4) and an aqueous solution of CA. The stability of CA on the presence of both polymers was investigated and it was observed tha...


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