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A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17b
Fuentes, J.; Guerreiro, P. M.; Modesto, Teresa; Rotllant, J.; Canario, Adelino V. M.; Power, DeborahEstradiol (E2) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hormone (PTH)-related protein (PTHrP) has been shown to be calciotropic in fish, we hypothesized that the two hormones could be mediating the same process. Sea bream (Sparus auratus) ju...
Stimulation of cortisol release by the N terminus of teleost parathyroid hormon...
Rotllant, J.; Guerreiro, P. M.; Anjos, Liliana; Redruello, Begoña; Canario, Adelino V. M.; Power, DeborahThe mode of action of PTHrP in the regulation of sea bream (Sparus auratus) interrenal cortisol production was studied in vitro using a dynamic superfusion system. Piscine (1–34)PTHrP (10−6–10−11 m) stimulated cortisol production in a dose-dependent manner. The ED50 of (1–34)PTHrP was 2.8 times higher than that of (1–39)ACTH, and maximum increase in cortisol production in response to 10−8 m of (1–34)PTHrP was a...
Calcium handling in Sparus auratus: effects of water and dietary calcium levels...
Abbink, W.; Bevelander, G. S.; Rotllant, J.; Canario, Adelino V. M.; Flik, G.Juvenile gilthead sea bream (Sparus auratus L.; 10–40·g body mass) were acclimatized in the laboratory to full strength (34‰) or dilute (2.5‰) seawater and fed normal, calcium-sufficient or calcium-deficient diet for nine weeks. Mean growth rate, whole-body calcium and phosphorus content and accumulation rates were determined, as well as plasma levels of ionic and total calcium, cortisol and parathyroid hormone...
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