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Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...

Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 C...

Mitoxantrone (MTX) is a chemotherapeutic agent that emerged as an alternative to anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress and mitochondrial-impaired function proposed as possible mechanisms. This work aimed to investigate the relevance of these mechanisms to the MTX toxicity in H9c2 cells, using therapeutic concentrations. The observed cytotoxicity of MTX was t...

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...

Mestrado em Toxicologia Analítica Clínica e Forense ; MSc in Analytical, Clinical and Forensic Toxicology

Avaliação quimiotaxonômica de cogumelos da espécie Psilocybe wrightii

A psilocibina e a psilocina são alcalóides com estrutura análoga a da serotonina e reconhecida ação alucinógena, produzindo efeitos profundos em humanos, como alucinações visuais e distúrbios sensoriais. Considerando que não há relatos de estudos químicos sobre a espécie Psilocybe wrightii, o presente trabalho objetivou avaliar o seu conteúdo alucinógeno. Os espécimes analisados foram coletados na região de San...

Análise do polimorfismo R72P do gene TP53 em pacientes com carcinoma de mama du...

Banco regional de DNA de mama e ovário do Hospital de Clínicas de Porto Alegre ...

Estabelecimento de um protocolo para análise de haplótipos em pacientes com muc...