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Design of polymeric nanoparticles and its applications as drug delivery systems...
Reis, C. P.; Martinho, N.; Rosado, C.; Fernandes, A. S.; Roberto, A.Objective: The aim of this study was to evaluate a formulation made of poly(lactide-co-glycolide) (PLGA) nanoparticles containing azelaic acid for potential acne treatment. Methods: Azelaic acid-loaded PLGA nanoparticles were prepared by spontaneous emulsification processes using poloxamer 188 as stabilizer. Several manufacturing parameters such as stirring rate, concentration of stabilizer and different recov...
Topical caffeine delivery using biocellulose membranes: a potential innovative ...
Silva, N. H.; Drumond, I.; Almeida, I. F.; Costa, P.; Rosado, C. F.; Neto, C. P.; Freire, C. S.; Silvestre, A. J.In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies wit...
Drug carriers for oral delivery of peptides and proteins: accomplishments and f...
Reis, CP; Silva, C; Martinho, N; Rosado, CEffective formulation for peptide and protein delivery through the oral route has always been the critical effort with the advent of biotechnology. Stability, enzymatic degradation and ineffective absorption are common difficulties found for conventional dosage forms. As a result, new drug-delivery approaches are used to circumvent these limitations and enhance effective oral drug delivery. Some of these techno...
Bacterial cellulose membranes as transdermal delivery systems for diclofenac: I...
Silva, N. H.; Rodrigues, A. F.; Almeida, I. F.; Costa, P. C.; Rosado, C.; Neto, C. P.; Silvestre, A. J.; Freire, C. S.Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite...
Hydrocortisone-loaded poly(ε-caprolactone) nanoparticles for atopic dermatitis ...
Rosado, C.; Silva, C.; Reis, C. P.Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects mostly young infants. The purpose of this research was to achieve a prolonged drug release and the reduction of side effects with hydrocortisone-loaded nanoparticles (NPs), for AD treatment. Poly(ε-caprolactone) (PCL) NPs were prepared by modified solvent displacement method and were characterized in terms of size, potential zeta, morp...
Pesquisa de propriedades anti-inflamatórias da planta Prunus lusitanica = Searc...
Duarte, P. Gonçalves; Costa, Maria do Céu; Rosado, C.; Teixeira, Adriano; Rodrigues, A. L.As formulações actuais para aplicação na pele devem satisfazer requisitos de eficácia elevada, compatibilidade cutânea e atracção estética. É geralmente aceite que o desempenho de um produto cosmético está relacionado com a tecnologia de todas as etapas da formulação. Assim, uma forma galénica óptima é um pré-requisito tão necessário para sucesso no mercado como a incorporação dos ingredientes activos adequados...
Pasture intake improves the performance and meat sensory attributes of free-ran...
Ponte, P.I.P; Rosado, C.M.C; Crespo, J.P.; Crespo, D.G; Mourão, José Luís; Chaveiro-Soares, M.A.; Mendes, I.L.T.; Gama, L.T.; Prates, J.A.M.Free-range chickens are assumed to consume low to moderate levels of pasture, although the effects of forage intake in broiler performance and poultry meat quality remain to be established. In addition, despite cellulases and hemicellulases being widely used as feed supplements to improve the nutritive value of cereal-based diets for fast-growing broilers, the potential interest of these biocatalysts in the pro...
Produção de frangos de carne em pastagens à base de Leguminosas
Ponte, P.I.P; Rosado, C.M.C; Crespo, J.P; Crespo, D.G; Chaveiro-Soares, M.A; Mourão, J.L; Mendes, I; Gama, L.T; Prates, J.A.M; Ferreira, L.M.APortugal apresenta reconhecidas potencialidades edafoclimáticas para a produção de pastagens à base de leguminosas, tanto em condições de regadio como de sequeiro. Este trabalho pretendeu avaliar a possibilidade de desenvolver formas alternativas para a produção de frangos de carne em pastagens. Avaliou-se o desempenho produtivo de frangos RedBro Cou Nu x RedBro M mantidos dos 28 aos 56 dias em pastagens de se...
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