Background: Atherosclerotic lesions commonly develop at arterial branch sites. Noninvasive carotid artery ultrasound is a well-established and effective method which allows real-time images and measurements of flow velocities. We aimed to develop a methodology for patient-specific computational 3D reconstruction and blood flow simulation based on ultrasound image data. Material and Methods: Subject-specific stu...
Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon-[gamma] (IFN-[gamma]). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. ; http://www.sciencedirect.com/science/article/B6TBB-4MCW9PR-1/1/bc45a63c4693fa42da0b7c7b88fbc990
Background: Asthma is a chronic inflammatory disorder of the airways. The persistence of airway inflammation depends on a decrease in apoptosis of T lymphocytes and eosinophils and survival of these activated cells. T lymphocytes expressing gamma delta receptors can be identified in human lungs and play an important role in immune defence against pathogens and in the regulation of chronic inflammation. Aging is...
Efectuámos a avaliação da situação clínica de 6 doentes com uveítes intermédias graves, tratados com Ciclosporina A, nos quais doseámos a alfa1 antitripsina no soro e aquoso antes e ao fim de um mês de terapêutica. Verificámos que, quer antes (p<0,05), quer ao fim de um mês (p<0,01), os valores do aquoso estão significativamente elevados em relação aos controles, o que não acontece no soro, havendo mesmo uma su...
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