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Impaired glucose transporter-1 degradation and increased glucose transport and ...
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando; Mobasheri, Ali; Lopes, Celeste; Mendes, Alexandrina F.Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intr...
Nitric oxide synthase isoforms and NF-jB activity in normal and osteoarthritic ...
Rosa, Susana C.; Judas, F.; Lopes, M. C.; Mendes, A. F.To elucidate the role of endogenous inducible nitric oxide (NO) on the regulation of NF-jB activity in human chondrocytes, we evaluated (i) the pattern of expression of the neuronal (nNOS) and inducible (iNOS) NO synthase isoforms and the basal NF-jB activity in normal and osteoarthritic (OA) human chondrocytes, (ii) the role of cytokines and growth factors in modulating the protein levels of the two NOS isofor...
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