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Screening of five essential oils for identification of potential inhibitors

Nuclear factor-kappaB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1beta (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-kappaB activation and NO production in human articula...

Expression and function of the insulin receptor in normal and osteoarthritic hu...

Objective Chondrocytes respond to insulin, but the presence and role of the specific high affinity insulin receptor (InsR) has never been demonstrated. This study determined whether human chondrocytes express the InsR and compared its abundance and function in normal and osteoarthritis (OA) human chondrocytes. Design Cartilage sections were immunostained for detection of the InsR. Non-proliferating chondrocyt...

Análise microestrutural, composicional e dureza das cerâmicas indígenas do síti...

Cerâmicas arqueológicas possuem uma infinidade de dados sobre a dinâmica social e cultural dos indígenas do sítio Caninhas, SP. A superfície de fratura apresenta gradiente de cor, do ocre ao cinza escuro, quando da superfície para o centro da peça. Este aspecto é decorrente dos gradientes de temperatura gerados durante a queima da peça cerâmica, de forma que na superfície a combustão dos compostos orgânicos é c...

Germinação de sementes de sete espécies medicinais nativas do sul do Brasil

Foram verificadas as condições ambientais de temperatura e de luz para germinação de diásporos de Borreria verticillata, Cayponia martiana, Echinodorus grandiflorus, Ocimum selloi, Plantago australis, Polygonum hydropiperoides e Waltheria douradinha. A germinação foi efetuada em placas de petri usando como substrato agar 1% ou em placas de gerbox com areia, em câmaras BOD, nas temperaturas constantes de 10 e 15...

Allergy to Extensively Hydrolysed Formulas

Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts:...

Chondrocyte survival is a major goal for the effective storage and clinical performance of human osteochondral allografts. The majority of animal and human cryopreservation studies conducted so far have been performed in small osteochondral cylinders. Using human tibial plateaus as a model for large osteochondral pieces, this work sought to evaluate the cryoprotective efficiency of glycerol and dimethylsulfoxid...

The use of stem cells for the treatment of autoimmune diseases

Autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. Nevertheless, some patients become resistant to conventional therapy. The use of high doses of drugs in such cases results in the need for bone marrow reconstitution, a situation which has stimulated research into the u...

Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts:...

Chondrocyte survival is a major goal for the effective storage and clinical performance of human osteochondral allografts. The majority of animal and human cryopreservation studies conducted so far have been performed in small osteochondral cylinders. Using human tibial plateaus as a model for large osteochondral pieces, this work sought to evaluate the cryoprotective efficiency of glycerol and dimethylsulfoxid...

Células Reguladoras

O papel das células T reguladoras na indução e manutenção da tolerância periférica tem recebido uma atenção crescente nos últimos anos. Foram descritos vários subgrupos de células T reguladoras, com base em marcadores de superfície e na produção de citocinas, não havendo no entanto marcadores específicos para nenhum destes subgrupos, pelo que a sua classificação se baseia no seu mecanismo de supressão. Desconhe...

Allelopathic plants. XVIII. Solanum nigrum L.

Solanum nigrum is a noxious weed worldwide and increasingly resistant to herbicides. It produces several alkaloids, flavonoids, saponins, sapogenins and hydroxycinnamic acid amides. Secondary chemicals produced by S. nigrum are fungitoxic and phytotoxic but their inhibitory effects are more intense to crops than to weeds. On the other hand, common phenolic acids, extracts and residues of several crop species ca...