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T Cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio; Rodrigues, Bruno Cerqueira; Roque, Susana; Silva, Palmira Barreira; Behar, Samuel M.; Neves, Margarida CorreiaThe thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
T cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio Nunes; Rodrigues, Bruno Miguel Cerqueira; Roque, Susana; Silva, Palmira Barreira da; Behar, Samuel M.The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nan...
Pereira, Vitor H.; Salgado, A. J.; Oliveira, Joaquim M.; Cerqueira, Susana R.; Frias, A. M.; Fraga, J. S.; Roque, Susana; Falcão, Ana M.Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles (CMCht/PAMAM) have recently been proposed for intracellular drug delivery purposes. These are constituted by a PAMAM dendrimer core grafted with chains of CMCht. Previous reports have shown that these nanoparticles disclosed an improved cytotoxic profile when compared to traditional dendrimers. Following on these results the present study aims to as...
Interplay between depressive-like behavior and the immune system in an animal m...
Roque, Susana; Oliveira, Tiago Gil; Nóbrega, Cláudia; Silva, Palmira Barreira; Alves, Cláudio Nunes; Sousa, Nuno; Palha, Joana AlmeidaGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression,...
Parameters of thyroid function throughout and after pregnancy in an iodine-defi...
Joana Almeida Santos Pacheco Palha; Costeiro, Maria Jos??; Oliveira, Pedro; Ares, Susana; Roque, Susana; Morreale de Escobar, GabriellaBACKGROUND: The thyroid hormone milieu is of crucial importance for the developing fetus. Pregnancy induces physiological changes in thyroid homeostasis that are influenced by the iodine status. However, longitudinal studies addressing thyroid function during pregnancy and after delivery are still lacking in mild-to-moderate iodine-deficient populations. Here we characterize the serum parameters of thyroid func...
Interleukin-10 : a key cytokine in depression?
Roque, Susana; Neves, Margarida Correia; Mesquita, Ana Raquel Marcelino; Palha, Joana Almeida; Sousa, NunoAn increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the...
IL-10 modulates depressive-like behavior
Mesquita, Ana Raquel Marcelino; Neves, Margarida Correia; Roque, Susana; Castro, António G.; Vieira, Paulo; Pedrosa, Jorge; Palha, Joana AlmeidaThe role of pro-inflammatory cytokines in psychiatric disorders has been the focus of great research attention in recent years. Para- doxically, the same is not true for anti-inflammatory cytokines. In the present study, we assessed the behavioral profile of animals with altered expression of the anti-inflammatory cytokine IL-10. We performed a battery of tests to assess anxiety, depressive-like and cognitive b...
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