Encontrados 2 documentos, a visualizar página 1 de 1
Enzymatic synthesis of antibody-human serum albumin conjugate for targeted drug...
Rollett, Alexandra; Thallinger, Barbara; Ohradanova-Repic, Anna; Machacek, Christian; Walenta, Evelyn; Paulo, Artur Cavaco; Birner-Gruenberger, RuthHighly specific targeted drug delivery devices can be obtained with antibody-human serum albumin (mAb-HSA) conjugates. However, their conventional production involves several reaction steps including chemical modification and activation of both proteins followed by cross-linking often involving toxic chemicals. Here, we describe the enzymatic synthesis of mAb-HSA conjugates for targeted drug delivery devices us...
Folic acid-functionalized human serum albumin nanocapsules for targeted drug de...
Rollett, Alexandra; Reiter, Tamara; Nogueira, Patrícia; Cardinale, Massimiliano; Loureiro, A.; Gomes, Andreia; Paulo, Artur Cavaco; Moreira, AlexandraActivated synovial macrophages play a key role in Rheumatoid Arthritis (RA). Recent studies have shown that folate receptor beta (FRβ) is specifically expressed by activated macrophages. Therefore a folate-based nanodevice would provide the possibility of delivering therapeutic agents to activated macrophages without affecting normal cells and tissues. This study shows for the first time the sonochemical prepa...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||