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Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer ce...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Rohde, Mikkel; Wilson, Cristina PereiraPurpose: Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to test the ability of quercetin (Q) and luteolin (L) to increase sensitivity of MSI CRC cells to 5-FU and characterize the dependence of the effects on cells´ p53 status. Methods: Two MSI huma...
Autophagy triggered by ursolic acid synergistically enhances 5-fluorouracil ind...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Rohde, Mikkel; Wilson, Cristina PereiraColorectal carcinoma (CRC) is a common cause of cancer-related death and tumors with microsatellite instability (MSI) and p53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU). Therefore, it is essential to find compounds that could contribute to treatment efficacy by increasing the sensitivity to 5-FU. HCT15, a MSI human CRC derived cell line that harbours a p53 mutation, was...
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