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Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an ...
Sereno, José; Rodrigues-Santos, Paulo; Vala, HelenaCyclosporin A (CsA), a calcineurin inhibitor, remain the cornerstone of immunosuppressive regimens, regardless of nephrotoxicity, which depends on the duration of drug exposure. The mechanisms and biomarkers underlying the transition from CsA-induced renal dysfunction to nephrotoxicity deserve better elucidation, and would help clinical decisions. This study aimed to clarify these issues, using a rat model of s...
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in...
Mega, Cristina; Vala, Helena; Rodrigues-Santos, Paulo; Oliveira, Jorge; Teixeira, Frederico; Fernandes, Rosa; Reis, Flávio; Lemos, Edite Teixeira deBackground: The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal model of type 2 diabetes mellitus (T2DM), the Zucker Diabetic Fatty (ZDF) rat, focusing on glycaemic, insulinic and lipidic profiles, as well as, on apoptosis, inflammation, angiogenesis and prol...
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